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Literature DB >> 25277684

The function of nicotinamide phosphoribosyltransferase in the heart.

Chiao-Po Hsu¹, Takanobu Yamamoto², Shinichi Oka², Junichi Sadoshima³.

Abstract

In addition to its roles as a coenzyme and an electron transfer molecule, nicotinamide adenine dinucleotide (NAD+) has emerged as a substrate of sirtuins, a family of enzymes that control aging and metabolism. Nicotinamide phosphoribosyltransferase (Nampt), a rate-limiting enzyme in the NAD+ salvage pathway, plays an important role in controlling the level of NAD+ and the activity of Sirt1 in the heart and the cardiomyocytes therein. Nampt protects the heart from ischemia and reperfusion injury by stimulating Sirt1. In this review, we summarize what is currently known regarding the function of Nampt in the heart.

Entities: CellLine Chemical Disease Gene Species

Keywords: Apoptosis; Heart; Ischemia; NAD+; Reperfusion; Sirt1

Mesh：

Substances：

Year: 2014 PMID： 25277684 PMCID： PMC4254158 DOI： 10.1016/j.dnarep.2014.08.005

Source DB: PubMed Journal: DNA Repair (Amst) ISSN： 1568-7856

51 in total

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Authors: L Guarente
Journal: Genes Dev Date: 2000-05-01 Impact factor: 11.361

2. Molecular cloning, chromosomal localization, tissue mRNA levels, bacterial expression, and enzymatic properties of human NMN adenylyltransferase.

Authors: M Emanuelli; F Carnevali; F Saccucci; F Pierella; A Amici; N Raffaelli; G Magni
Journal: J Biol Chem Date: 2001-01-05 Impact factor: 5.157

3. Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6.

Authors: Yi Cai; Shan-Shan Yu; Shao-Rui Chen; Rong-Biao Pi; Si Gao; Hong Li; Jian-Tao Ye; Pei-Qing Liu
Journal: FEBS Lett Date: 2012-02-20 Impact factor: 4.124

4. Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia.

Authors: Pei Wang; Yun-Feng Guan; Hui Du; Qi-Wei Zhai; Ding-Feng Su; Chao-Yu Miao
Journal: Autophagy Date: 2012-01-01 Impact factor: 16.016

Review 5. Visfatin/NAMPT: a multifaceted molecule with diverse roles in physiology and pathophysiology.

Authors: Tuva B Dahl; Sverre Holm; Pål Aukrust; Bente Halvorsen
Journal: Annu Rev Nutr Date: 2012-03-29 Impact factor: 11.848

6. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase.

Authors: S Imai; C M Armstrong; M Kaeberlein; L Guarente
Journal: Nature Date: 2000-02-17 Impact factor: 49.962

7. A profile of differentially expressed genes in primary colorectal cancer using suppression subtractive hybridization.

Authors: S E Hufton; P T Moerkerk; R Brandwijk; A P de Bruïne; J W Arends; H R Hoogenboom
Journal: FEBS Lett Date: 1999-12-10 Impact factor: 4.124

Review 8. Protection of the heart against ischemia/reperfusion by silent information regulator 1.

Authors: Takanobu Yamamoto; Junichi Sadoshima
Journal: Trends Cardiovasc Med Date: 2011-01 Impact factor: 6.677

9. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.

Authors: Carles Cantó; Riekelt H Houtkooper; Eija Pirinen; Dou Y Youn; Maaike H Oosterveer; Yana Cen; Pablo J Fernandez-Marcos; Hiroyasu Yamamoto; Pénélope A Andreux; Philippe Cettour-Rose; Karl Gademann; Chris Rinsch; Kristina Schoonjans; Anthony A Sauve; Johan Auwerx
Journal: Cell Metab Date: 2012-06-06 Impact factor: 27.287

10. AMPK regulates circadian rhythms in a tissue- and isoform-specific manner.

Authors: Jee-Hyun Um; Julie S Pendergast; Danielle A Springer; Marc Foretz; Benoit Viollet; Alexandra Brown; Myung K Kim; Shin Yamazaki; Jay H Chung
Journal: PLoS One Date: 2011-03-31 Impact factor: 3.240

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Authors: Joanna M S Davies; Josiane Cillard; Bertrand Friguet; Enrique Cadenas; Jean Cadet; Rachael Cayce; Andrew Fishmann; David Liao; Anne-Laure Bulteau; Frédéric Derbré; Amélie Rébillard; Steven Burstein; Etienne Hirsch; Robert A Kloner; Michael Jakowec; Giselle Petzinger; Delphine Sauce; Florian Sennlaub; Isabelle Limon; Fulvio Ursini; Matilde Maiorino; Christina Economides; Christian J Pike; Pinchas Cohen; Anne Negre Salvayre; Matthew R Halliday; Adam J Lundquist; Nicolaus A Jakowec; Fatima Mechta-Grigoriou; Mathias Mericskay; Jean Mariani; Zhenlin Li; David Huang; Ellsworth Grant; Henry J Forman; Caleb E Finch; Patrick Y Sun; Laura C D Pomatto; Onnik Agbulut; David Warburton; Christian Neri; Mustapha Rouis; Pierre Cillard; Jacqueline Capeau; Jean Rosenbaum; Kelvin J A Davies
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2. NAD(H) in mitochondrial energy transduction: implications for health and disease.

Authors: Matthew A Walker; Rong Tian
Journal: Curr Opin Physiol Date: 2018-04-11

Review 3. Role of NAD⁺ and mitochondrial sirtuins in cardiac and renal diseases.

Authors: Kathleen A Hershberger; Angelical S Martin; Matthew D Hirschey
Journal: Nat Rev Nephrol Date: 2017-02-06 Impact factor: 28.314

4. Cardioprotective Effects of 1-(3,6-Dibromo-carbazol-9-yl)-3-Phenylamino-Propan-2-Ol in Diabetic Hearts via Nicotinamide Phosphoribosyltransferase Activation.

Authors: Jared Tur; Sachin L Badole; Ravikumar Manickam; Kalyan C Chapalamadugu; Wanling Xuan; Wayne Guida; Jaret J Crews; Kirpal S Bisht; Srinivas M Tipparaju
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5. Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy.

Authors: Nicolas Diguet; Samuel A J Trammell; Cynthia Tannous; Robin Deloux; Jérôme Piquereau; Nathalie Mougenot; Anne Gouge; Mélanie Gressette; Boris Manoury; Jocelyne Blanc; Marie Breton; Jean-François Decaux; Gareth G Lavery; István Baczkó; Joffrey Zoll; Anne Garnier; Zhenlin Li; Charles Brenner; Mathias Mericskay
Journal: Circulation Date: 2017-12-07 Impact factor: 29.690

The function of nicotinamide phosphoribosyltransferase in the heart.

Review 1. Sir2 links chromatin silencing, metabolism, and aging.

2. Molecular cloning, chromosomal localization, tissue mRNA levels, bacterial expression, and enzymatic properties of human NMN adenylyltransferase.

3. Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6.

4. Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia.

Review 5. Visfatin/NAMPT: a multifaceted molecule with diverse roles in physiology and pathophysiology.

6. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase.

7. A profile of differentially expressed genes in primary colorectal cancer using suppression subtractive hybridization.

Review 8. Protection of the heart against ischemia/reperfusion by silent information regulator 1.

9. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.

10. AMPK regulates circadian rhythms in a tissue- and isoform-specific manner.

Review 1. The Oxygen Paradox, the French Paradox, and age-related diseases.

2. NAD(H) in mitochondrial energy transduction: implications for health and disease.

Review 3. Role of NAD⁺ and mitochondrial sirtuins in cardiac and renal diseases.

4. Cardioprotective Effects of 1-(3,6-Dibromo-carbazol-9-yl)-3-Phenylamino-Propan-2-Ol in Diabetic Hearts via Nicotinamide Phosphoribosyltransferase Activation.

5. Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy.

6. Nicotinamide riboside kinase-2 alleviates ischemia-induced heart failure through P38 signaling.

Review 7. Cardiac Energy Metabolism in Heart Failure.

8. Kruppel-Like Factor 15 Regulates the Circadian Susceptibility to Ischemia Reperfusion Injury in the Heart.

Review 9. The cardiovascular impact of visfatin - an inflammation predictor biomarker in metabolic syndrome.

Review 10. Nicotinamide Riboside-The Current State of Research and Therapeutic Uses.

Review 1. Sir2 links chromatin silencing, metabolism, and aging.

Review 5. Visfatin/NAMPT: a multifaceted molecule with diverse roles in physiology and pathophysiology.

Review 8. Protection of the heart against ischemia/reperfusion by silent information regulator 1.

Review 1. The Oxygen Paradox, the French Paradox, and age-related diseases.

Review 3. Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases.

Review 7. Cardiac Energy Metabolism in Heart Failure.

Review 9. The cardiovascular impact of visfatin - an inflammation predictor biomarker in metabolic syndrome.

Review 10. Nicotinamide Riboside-The Current State of Research and Therapeutic Uses.

Review 3. Role of NAD⁺ and mitochondrial sirtuins in cardiac and renal diseases.