Irene M Mulder1, Eva B Deerenberg2, Willem A Bemelman3, Johannes Jeekel4, Johan F Lange2. 1. Laboratory of Experimental Surgery, Department of Surgery, Erasmus University Medical Center, Room Ee-173, P.O. Box 2040, Rotterdam 3000, The Netherlands. Electronic address: irenemulder84@hotmail.com. 2. Laboratory of Experimental Surgery, Department of Surgery, Erasmus University Medical Center, Room Ee-173, P.O. Box 2040, Rotterdam 3000, The Netherlands. 3. Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands. 4. Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
Abstract
BACKGROUND: This experimental study investigates infectious complications and functional outcome of biological meshes in a contaminated environment. METHODS: In 90 rats peritonitis was induced, and after 24 hours, a biological mesh was implanted intraperitoneally including 2 non-crosslinked mesh groups (Strattice and Surgisis) and 2 crosslinked mesh groups (CollaMendFM and Permacol). Sacrifice was after 90 and 180 days. RESULTS: More mesh infections occurred in crosslinked meshes compared with non-crosslinked meshes (70% vs 4%; P < .001). Mesh infection was the highest in crosslinked CollaMendFM (81.2%) and lowest in non-crosslinked Strattice groups (0%). Incorporation into the abdominal wall was poor in all meshes (0% to 39%). After 180 days no residue of non-crosslinked Surgisis mesh was found. After 180 days, shrinkage was .8% in crosslinked Permacol and 20% in Strattice groups. Strattice showed the least adhesion formation (median 5%). CONCLUSIONS: Infection rate of biological meshes in a contaminated field was the highest in crosslinked meshes. All biological meshes showed poor incorporation, which makes long-term abdominal wall repair questionable.
BACKGROUND: This experimental study investigates infectious complications and functional outcome of biological meshes in a contaminated environment. METHODS: In 90 ratsperitonitis was induced, and after 24 hours, a biological mesh was implanted intraperitoneally including 2 non-crosslinked mesh groups (Strattice and Surgisis) and 2 crosslinked mesh groups (CollaMendFM and Permacol). Sacrifice was after 90 and 180 days. RESULTS: More mesh infections occurred in crosslinked meshes compared with non-crosslinked meshes (70% vs 4%; P < .001). Mesh infection was the highest in crosslinked CollaMendFM (81.2%) and lowest in non-crosslinked Strattice groups (0%). Incorporation into the abdominal wall was poor in all meshes (0% to 39%). After 180 days no residue of non-crosslinked Surgisis mesh was found. After 180 days, shrinkage was .8% in crosslinked Permacol and 20% in Strattice groups. Strattice showed the least adhesion formation (median 5%). CONCLUSIONS: Infection rate of biological meshes in a contaminated field was the highest in crosslinked meshes. All biological meshes showed poor incorporation, which makes long-term abdominal wall repair questionable.
Authors: O Guillaume; B Pérez Kohler; R Fortelny; H Redl; F Moriarty; R G Richards; D Eglin; A Petter Puchner Journal: Hernia Date: 2018-08-28 Impact factor: 4.739
Authors: J J Atema; E J Furnée; Y Maeda; J Warusavitarne; P J Tanis; W A Bemelman; C J Vaizey; M A Boermeester Journal: World J Surg Date: 2017-08 Impact factor: 3.352