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Literature DB >> 25277513

Finding a cure for human immunodeficiency virus-1 infection.

Joel N Blankson¹, Janet D Siliciano¹, Robert F Siliciano².

Abstract

Remarkable advances have been made in the treatment of human immunodeficiency virus (HIV)-1 infection, but in the entire history of the epidemic, only 1 patient has been cured. Herein we review the fundamental mechanisms that render HIV-1 infection difficult to cure and then discuss recent clinical and experimental situations in which some form of cure has been achieved. Finally, we consider approaches that are currently being taken to develop a general cure for HIV-1 infection.

Entities: Chemical

Keywords: Antiretroviral therapy; Cure; HIV; Latent reservoir; Retroviral persistence

Mesh：

Substances：
Anti-HIV Agents

Year: 2014 PMID： 25277513 PMCID： PMC4253590 DOI： 10.1016/j.idc.2014.08.007

Source DB: PubMed Journal: Infect Dis Clin North Am ISSN： 0891-5520 Impact factor: 5.982

113 in total

1. Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence.

Authors: M C Strain; H F Günthard; D V Havlir; C C Ignacio; D M Smith; A J Leigh-Brown; T R Macaranas; R Y Lam; O A Daly; M Fischer; M Opravil; H Levine; L Bacheler; C A Spina; D D Richman; J K Wong
Journal: Proc Natl Acad Sci U S A Date: 2003-04-08 Impact factor: 11.205

2. Immune control of HIV-1 after early treatment of acute infection.

Authors: E S Rosenberg; M Altfeld; S H Poon; M N Phillips; B M Wilkes; R L Eldridge; G K Robbins; R T D'Aquila; P J Goulder; B D Walker
Journal: Nature Date: 2000-09-28 Impact factor: 49.962

3. Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo.

Authors: Elizabeth J Beans; Dennis Fournogerakis; Carolyn Gauntlett; Lars V Heumann; Rainer Kramer; Matthew D Marsden; Danielle Murray; Tae-Wook Chun; Jerome A Zack; Paul A Wender
Journal: Proc Natl Acad Sci U S A Date: 2013-06-28 Impact factor: 11.205

4. Multi-step inhibition explains HIV-1 protease inhibitor pharmacodynamics and resistance.

Authors: S Alireza Rabi; Gregory M Laird; Christine M Durand; Sarah Laskey; Liang Shan; Justin R Bailey; Stanley Chioma; Richard D Moore; Robert F Siliciano
Journal: J Clin Invest Date: 2013-08-27 Impact factor: 14.808

5. Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication.

Authors: Tae-Wook Chun; J Shawn Justement; Danielle Murray; Claire W Hallahan; Janine Maenza; Ann C Collier; Prameet M Sheth; Rupert Kaul; Mario Ostrowski; Susan Moir; Colin Kovacs; Anthony S Fauci
Journal: AIDS Date: 2010-11-27 Impact factor: 4.177

6. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein.

Authors: Ann M Sheehy; Nathan C Gaddis; Jonathan D Choi; Michael H Malim
Journal: Nature Date: 2002-07-14 Impact factor: 49.962

7. Epidemiologic characteristics and natural history of HIV-1 natural viral suppressors.

Authors: Mohammad M Sajadi; Neil T Constantine; Dean L Mann; Manhattan Charurat; Elham Dadzan; Peter Kadlecik; Robert R Redfield
Journal: J Acquir Immune Defic Syndr Date: 2009-04-01 Impact factor: 3.731

8. New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma.

Authors: Sarah Palmer; Ann P Wiegand; Frank Maldarelli; Holly Bazmi; JoAnn M Mican; Michael Polis; Robin L Dewar; Angeline Planta; Shuying Liu; Julia A Metcalf; John W Mellors; John M Coffin
Journal: J Clin Microbiol Date: 2003-10 Impact factor: 5.948

9. Current and future therapies for hepatitis C virus infection.

Authors: Marc G Ghany; T Jake Liang
Journal: N Engl J Med Date: 2013-08-15 Impact factor: 91.245

10. New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo.

Authors: C Korin Bullen; Gregory M Laird; Christine M Durand; Janet D Siliciano; Robert F Siliciano
Journal: Nat Med Date: 2014-03-23 Impact factor: 53.440

15 in total

1. Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity.

Authors: Janet Karpinski; Ilona Hauber; Jan Chemnitz; Carola Schäfer; Maciej Paszkowski-Rogacz; Deboyoti Chakraborty; Niklas Beschorner; Helga Hofmann-Sieber; Ulrike C Lange; Adam Grundhoff; Karl Hackmann; Evelin Schrock; Josephine Abi-Ghanem; M Teresa Pisabarro; Vineeth Surendranath; Axel Schambach; Christoph Lindner; Jan van Lunzen; Joachim Hauber; Frank Buchholz
Journal: Nat Biotechnol Date: 2016-02-22 Impact factor: 54.908

Finding a cure for human immunodeficiency virus-1 infection.

1. Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence.

2. Immune control of HIV-1 after early treatment of acute infection.

3. Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo.

4. Multi-step inhibition explains HIV-1 protease inhibitor pharmacodynamics and resistance.

5. Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication.

6. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein.

7. Epidemiologic characteristics and natural history of HIV-1 natural viral suppressors.

8. New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma.

9. Current and future therapies for hepatitis C virus infection.

10. New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo.

1. Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity.

2. RNA stability regulates human T cell leukemia virus type 1 gene expression in chronically-infected CD4 T cells.

3. Novel Assays for Measurement of Total Cell-Associated HIV-1 DNA and RNA.

4. Identification of glycoproteins associated with HIV latently infected cells using quantitative glycoproteomics.

5. Gp120 binding with DC-SIGN induces reactivation of HIV-1 provirus via the NF-κB signaling pathway.

Review 6. The role of HIV integration in viral persistence: no more whistling past the proviral graveyard.

7. Bryostatin-1 Decreases HIV-1 Infection and Viral Production in Human Primary Macrophages.

8. Multifarious immunotherapeutic approaches to cure HIV-1 infection.

9. Women in HIV cure research: multilevel interventions to improve sex equity in recruitment.

10. Heat Shock Factor 1 Mediates Latent HIV Reactivation.