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Literature DB >> 25275905

LOXL1-associated candidate epithelial pathomechanisms in exfoliation glaucoma.

Rozalia Laczko¹, Kornelia M Szauter, Katalin Csiszar.

Abstract

Results of the present study support ocular epithelia-specific LOXL1 functions in exfoliation glaucoma that may include both dysregulated extracellular matrix cross-linking activity and cellular mechanisms involving a role for LOXL1, in direct interaction with Snail1, in promoting epithelial to mesenchymal transition and a potential shift towards fibrogenic epithelial cell phenotypes.

Entities: CellLine Chemical Disease Gene Mutation Species

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Year: 2014 PMID： 25275905 PMCID： PMC4205763 DOI： 10.1097/IJG.0000000000000105

Source DB: PubMed Journal: J Glaucoma ISSN： 1057-0829 Impact factor: 2.503

24 in total

1. Lysyl oxidase-like protein from bovine aorta. Isolation and maturation to an active form by bone morphogenetic protein-1.

Authors: A Borel; D Eichenberger; J Farjanel; E Kessler; C Gleyzal; D J Hulmes; P Sommer; B Font
Journal: J Biol Chem Date: 2001-10-29 Impact factor: 5.157

2. Regulation of lysyl oxidase-like 1 (LOXL1) and elastin-related genes by pathogenic factors associated with pseudoexfoliation syndrome.

Authors: Matthias Zenkel; Anita Krysta; Francesca Pasutto; Anselm Juenemann; Friedrich E Kruse; Ursula Schlötzer-Schrehardt
Journal: Invest Ophthalmol Vis Sci Date: 2011-10-31 Impact factor: 4.799

3. A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression.

Authors: Héctor Peinado; Maria Del Carmen Iglesias-de la Cruz; David Olmeda; Katalin Csiszar; Keith S K Fong; Sonia Vega; Maria Angela Nieto; Amparo Cano; Francisco Portillo
Journal: EMBO J Date: 2005-08-18 Impact factor: 11.598

Review 4. Molecular genetics in glaucoma.

Authors: Yutao Liu; R Rand Allingham
Journal: Exp Eye Res Date: 2011-08-18 Impact factor: 3.467

5. Comparative immunocytochemical localization of lysyl oxidase (LOX) and the lysyl oxidase-like (LOXL) proteins: changes in the expression of LOXL during development and growth of mouse tissues.

Authors: Kimiko Hayashi; Keith S K Fong; Frederic Mercier; Charles D Boyd; Katalin Csiszar; Masando Hayashi
Journal: J Mol Histol Date: 2004-11 Impact factor: 2.611

6. Transforming growth factor-beta induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells.

Authors: Anirudh Sethi; Weiming Mao; Robert J Wordinger; Abbot F Clark
Journal: Invest Ophthalmol Vis Sci Date: 2011-07-15 Impact factor: 4.799

2. Cleavage of LOXL1 by BMP1 and ADAMTS14 Proteases Suggests a Role for Proteolytic Processing in the Regulation of LOXL1 Function.

Authors: Tamara Rosell-García; Sergio Rivas-Muñoz; Alain Colige; Fernando Rodriguez-Pascual
Journal: Int J Mol Sci Date: 2022-03-18 Impact factor: 5.923

2 in total

LOXL1-associated candidate epithelial pathomechanisms in exfoliation glaucoma.

1. Lysyl oxidase-like protein from bovine aorta. Isolation and maturation to an active form by bone morphogenetic protein-1.

2. Regulation of lysyl oxidase-like 1 (LOXL1) and elastin-related genes by pathogenic factors associated with pseudoexfoliation syndrome.

3. A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression.

Review 4. Molecular genetics in glaucoma.

5. Comparative immunocytochemical localization of lysyl oxidase (LOX) and the lysyl oxidase-like (LOXL) proteins: changes in the expression of LOXL during development and growth of mouse tissues.

6. Transforming growth factor-beta induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells.

7. Fibrosis: recent advances in myofibroblast biology and new therapeutic perspectives.

8. Epithelial mesenchymal transition-like phenomenon in trabecular meshwork cells.

9. High glucose induced differential expression of lysyl oxidase and its isoform in ARPE-19 cells.

10. Genetics and genomics of pseudoexfoliation syndrome/glaucoma.

1. Hepatocyte PRMT1 protects from alcohol induced liver injury by modulating oxidative stress responses.

2. Cleavage of LOXL1 by BMP1 and ADAMTS14 Proteases Suggests a Role for Proteolytic Processing in the Regulation of LOXL1 Function.