Antonio Macrì1, Vincenzo Arcoraci2, Valerio Belgrano3, Marina Caldana4, Tommaso Cioppa5, Barbara Costantini6, Eugenio Cucinotta7, Franco De Cian3, Pierandrea De Iaco8, Giovanni De Manzoni4, Angelo Di Giorgio9, Francesco Fleres7, Francesca Muffatti10, Elena Orsenigo10, Antonio Daniele Pinna11, Franco Roviello5, Paolo Sammartino9, Giovanni Scambia6, Edoardo Saladino7. 1. Department of Human Pathology, University of Messina, Messina, Italy amacri@unime.it. 2. Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy. 3. Department of Surgery, University of Genoa, Genoa, Italy. 4. 1st Department of General Surgery, University of Verona, Verona, Italy. 5. Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy. 6. Department of Obstetrics & Gynaecology, Catholic University of Sacred Heart, Rome, Italy. 7. Department of Human Pathology, University of Messina, Messina, Italy. 8. Gynecologic Oncology Unit, S. Orsola-Malpighi Hospital, Bologna, Italy. 9. Department of Surgery "Pietro Valdoni", University "Sapienza" of Rome, Rome, Italy. 10. Department of Surgery, San Raffaele Scientific Institute, Milan, Italy. 11. Department of Medical and Surgical Sciences, S. Orsola-Malpighi Hospital, Bologna, Italy.
Abstract
AIM: To assess the incidence of morbidity and mortality of Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy. PATIENTS AND METHODS: A retrospective multicentric study was performed. Six hundred and eighty-three patients were recorded. Predictors of morbidity and mortality were evaluated with univariate and multivariate analysis. RESULTS: In univariate analysis, older age, Eastern Cooperative Oncology Group score, a greater value of Peritoneal Cancer Index (PCI) and sub-optimal cytoreduction were correlated with higher mortality, while older age, presence of ascites, ovarian origin of carcinomatosis, closed technique, a greater value of PCI, longer operative time and sub-optimal cytoreduction were predictors of higher morbidity. In multivariate analysis, older age and a greater value of PCI were correlated with higher mortality; older age, ovarian origin of tumor, presence of ascites, closed technique and longer operative time were predictors of higher morbidity. CONCLUSION: Careful patient selection has to be performed to improve clinical outcomes. Copyright
AIM: To assess the incidence of morbidity and mortality of Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy. PATIENTS AND METHODS: A retrospective multicentric study was performed. Six hundred and eighty-three patients were recorded. Predictors of morbidity and mortality were evaluated with univariate and multivariate analysis. RESULTS: In univariate analysis, older age, Eastern Cooperative Oncology Group score, a greater value of Peritoneal Cancer Index (PCI) and sub-optimal cytoreduction were correlated with higher mortality, while older age, presence of ascites, ovarian origin of carcinomatosis, closed technique, a greater value of PCI, longer operative time and sub-optimal cytoreduction were predictors of higher morbidity. In multivariate analysis, older age and a greater value of PCI were correlated with higher mortality; older age, ovarian origin of tumor, presence of ascites, closed technique and longer operative time were predictors of higher morbidity. CONCLUSION: Careful patient selection has to be performed to improve clinical outcomes. Copyright
Authors: V López-López; P A Cascales-Campos; E Gil; J Arevalo; A Gonzalez; J Gil; F C Muñoz-Casares; J T Melero; P Barrios; R Morales; I Ramos; G Ortega; B Camps; L González-Bayón; P Bretcha-Boix; J Farré-Alegre; S González-Moreno; P Parrilla Journal: Clin Transl Oncol Date: 2017-08-10 Impact factor: 3.405
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