Junichiro Ishioka1, Hitoshi Masuda2, Toshiki Kijima3, Manabu Tatokoro3, Soichiro Yoshida3, Minato Yokoyama3, Yoh Matsuoka3, Noboru Numao3, Fumitaka Koga3, Kazutaka Saito3, Yasuhisa Fujii3, Yasuyuki Sakai4, Chizuru Arisawa5, Tetsuo Okuno6, Katsuhi Nagahama7, Shigeyoshi Kamata8, Junji Yonese2, Yukio Kageyama9, Akira Noro10, Shinji Morimoto11, Toshihiko Tsujii12, Satoshi Kitahara13, Shuichi Gotoh14, Kazunori Kihara3. 1. Department of Urology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan ishiuro@tmd.ac.jp. 2. Department of Urology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan. 3. Department of Urology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan. 4. Department of Urology, National Cancer Center Hospital East, Chiba, Japan. 5. Department of Urology, East Tokyo Metropolitan Hospital, Tokyo, Japan. 6. Department of Urology, JA Toride Medical Center, Ibaraki, Japan. 7. Department of Urology, Kounodai Hospital, National Center for Global Health and Medicine, Chiba, Japan. 8. Department of Urology, Soka Municipal Hospital, Saitama, Japan. 9. Department of Urology Saitama Cancer Center, Saitama, Japan. 10. Department of Urology, Saitama Red Cross Hospital, Saitama, Japan. 11. Department of Urology, Tsuchiura Kyodo General Hospital, Ibaraki, Japan. 12. Department of Urology, Tokyo Metropolitan Ohtsuka Hospital, Tokyo, Japan. 13. Department of Urology, Tama-Nanbu Chiiki Hospital, Tokyo, Japan. 14. Department of Urology, Hamamatsu Medical Center, Shizuoka, Japan.
Abstract
AIM: To clarify how body mass index (BMI) affects the risk of death from upper urinary tract urothelial carcinoma (UUTUC) we investigated the impact of BMI on UUTUC using a Japanese multicenter database. PATIENTS AND METHODS: Between January 1995 and December 2010, 1,329 patients with upper urinary tract tumors were treated in 13 institutions in Japan. From this group, a cohort of 1,014 patients treated with radical nephroureterectomy was retrospectively reviewed. BMI was categorized into the following three groups: BMI <22.5, BMI 22.5 to <25 and BMI ≥ 25. The association between each group and cancer-specific survival (CSS) was analyzed using Cox proportional hazards regression models. RESULTS: The median BMI was 22.4 kg/m(2) (interquartile range, 20.5-24.8). Out of all patients, 213 (21%) died of UUTUC. Hazard ratios of the BMI ≥ 25 and the BMI <22.5 group were 1.76 and 1.66, respectively. CONCLUSION: Both higher and lower BMI affect the prognosis of UUTUC treated with radical nephroureterectomy. Copyright
AIM: To clarify how body mass index (BMI) affects the risk of death from upper urinary tract urothelial carcinoma (UUTUC) we investigated the impact of BMI on UUTUC using a Japanese multicenter database. PATIENTS AND METHODS: Between January 1995 and December 2010, 1,329 patients with upper urinary tract tumors were treated in 13 institutions in Japan. From this group, a cohort of 1,014 patients treated with radical nephroureterectomy was retrospectively reviewed. BMI was categorized into the following three groups: BMI <22.5, BMI 22.5 to <25 and BMI ≥ 25. The association between each group and cancer-specific survival (CSS) was analyzed using Cox proportional hazards regression models. RESULTS: The median BMI was 22.4 kg/m(2) (interquartile range, 20.5-24.8). Out of all patients, 213 (21%) died of UUTUC. Hazard ratios of the BMI ≥ 25 and the BMI <22.5 group were 1.76 and 1.66, respectively. CONCLUSION: Both higher and lower BMI affect the prognosis of UUTUC treated with radical nephroureterectomy. Copyright