Ilona Wall1, Ingo G H Schmidt-Wolf2. 1. Center for Integrated Oncology (CIO), Med. Klinik und Poliklinik III, Universitätsklinikum Bonn, Bonn, Germany. 2. Center for Integrated Oncology (CIO), Med. Klinik und Poliklinik III, Universitätsklinikum Bonn, Bonn, Germany Ingo.Schmidt-Wolf@ukb.uni-bonn.de.
Abstract
BACKGROUND/AIM: Activated Wnt signaling in cancer cells leads to cell proliferation. It has been shown that the Wnt pathway is activated in pancreatic adenocarcinoma cells. Therefore, we tested the effect of Wnt inhibitors in human and murine pancreatic cancer cell lines. MATERIALS AND METHODS: The Wnt inhibitors ethacrynic acid (EA), ciclopirox olamine (CIC), piroctone olamine (PO) and griseofulvin (GF) were tested in murine and human pancreatic cancer cell lines with the 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide (MTT) assay. RESULTS: We showed that the Wnt inhibitors significantly reduced cell viability in murine, as well as human pancreatic cancer cell lines. CONCLUSION: These results may lead to a new therapeutic option with Wnt inhibitors for patients with pancreatic adenocarcinoma. Copyright
BACKGROUND/AIM: Activated Wnt signaling in cancer cells leads to cell proliferation. It has been shown that the Wnt pathway is activated in pancreatic adenocarcinoma cells. Therefore, we tested the effect of Wnt inhibitors in human and murinepancreatic cancer cell lines. MATERIALS AND METHODS: The Wnt inhibitors ethacrynic acid (EA), ciclopirox olamine (CIC), piroctone olamine (PO) and griseofulvin (GF) were tested in murine and humanpancreatic cancer cell lines with the 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide (MTT) assay. RESULTS: We showed that the Wnt inhibitors significantly reduced cell viability in murine, as well as humanpancreatic cancer cell lines. CONCLUSION: These results may lead to a new therapeutic option with Wnt inhibitors for patients with pancreatic adenocarcinoma. Copyright
Authors: Stephen J Murphy; Steven N Hart; Geoffrey C Halling; Sarah H Johnson; James B Smadbeck; Travis Drucker; Joema Felipe Lima; Fariborz Rakhshan Rohakhtar; Faye R Harris; Farhad Kosari; Subbaya Subramanian; Gloria M Petersen; Timothy D Wiltshire; Benjamin R Kipp; Mark J Truty; Robert R McWilliams; Fergus J Couch; George Vasmatzis Journal: Cancer Res Date: 2015-12-16 Impact factor: 12.701