Literature DB >> 2527426

The human T-cell receptor gamma (TRG) genes.

M P Lefranc, T H Rabbitts.   

Abstract

The human T-cell receptor gamma (TRG) chain genes, like those encoding the T-cell receptor alpha- and beta-polypeptides, undergo rearrangements specifically in T cells. The human TRG locus, which has been completely mapped, is composed of two constant region genes (TRGC), five joining segments (TRGJ) and at least 14 variable gamma-genes (TRGV). Eight variable genes are functional and belong to four different subgroups. The product of the rearranged TRG gene is the gamma-chain which is expressed, along with the delta-chain, at the surface of a subset of T lymphocytes. Although some gamma delta + cells display a cytolytic activity, their precise function remains to be elucidated.

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Year:  1989        PMID： 2527426     DOI： 10.1016/0968-0004(89)90029-7

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  19 in total

1.  Allelic polymorphism of T-cell receptor constant domains is widespread in fishes.

Authors:  Michael F Criscitiello; Niklas E Wermenstam; Lars Pilström; E Churchill McKinney
Journal:  Immunogenetics       Date:  2004-02-19       Impact factor: 2.846

2.  An STS in the human T cell receptor gamma locus (located at 7p14-15).

Authors:  F Bernard; P Chuchana; G Lefranc; M P Lefranc
Journal:  Nucleic Acids Res       Date:  1990-10-25       Impact factor: 16.971

3.  Restricted heterogeneity of T lymphocytes in combined immunodeficiency with hypereosinophilia (Omenn's syndrome).

Authors:  G de Saint-Basile; F Le Deist; J P de Villartay; N Cerf-Bensussan; O Journet; N Brousse; C Griscelli; A Fischer
Journal:  J Clin Invest       Date:  1991-04       Impact factor: 14.808

4.  Polymorphism of the T-cell receptor gamma variable and constant region genes in a Chinese population.

Authors:  N Ghanem; Z Soua; X G Zhang; M Zijun; Y Zhiwei; G Lefranc; M P Lefranc
Journal:  Hum Genet       Date:  1991-03       Impact factor: 4.132

5.  Comparative investigations of T cell receptor gamma gene rearrangements in frozen and formalin-fixed paraffin wax-embedded tissues by capillary electrophoresis.

Authors:  M Christensen; A D Funder; K Bendix; F B Soerensen
Journal:  J Clin Pathol       Date:  2006-02-06       Impact factor: 3.411

6.  Deletion, insertion, and restriction site polymorphism of the T-cell receptor gamma variable locus in French, Lebanese, Tunisian, and black African populations.

Authors:  N Ghanem; C Buresi; J P Moisan; M Bensmana; P Chuchana; S Huck; G Lefranc; M P Lefranc
Journal:  Immunogenetics       Date:  1989       Impact factor: 2.846

7.  T lymphocytes in giant cell arteritic lesions are polyclonal cells expressing alpha beta type antigen receptors and VLA-1 integrin receptors.

Authors:  C Schaufelberger; S Stemme; R Andersson; G K Hansson
Journal:  Clin Exp Immunol       Date:  1993-03       Impact factor: 4.330

8.  Bovine T cell receptor gamma variable and constant genes: combinatorial usage by circulating gammadelta T cells.

Authors:  Carolyn Herzig; Seth Blumerman; Marie-Paule Lefranc; Cynthia Baldwin
Journal:  Immunogenetics       Date:  2006-03-16       Impact factor: 2.846

9.  Allotype distribution of human T cell receptor beta and gamma chain genes in Caucasians, Asians and Australian aborigines: relevance to chronic hepatitis B.

Authors:  P Soeharso; K M Summers; W G Cooksley
Journal:  Hum Genet       Date:  1992-04       Impact factor: 4.132

Review 10.  Human T-cell receptor variable gene segment families.

Authors:  B Arden; S P Clark; D Kabelitz; T W Mak
Journal:  Immunogenetics       Date:  1995       Impact factor: 2.846
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