Literature DB >> 25273170

Downregulation of MLL3 in esophageal squamous cell carcinoma is required for the growth and metastasis of cancer cells.

Manhui Xia1, Lifang Xu, Yunhua Leng, Feng Gao, Hong Xia, Diandian Zhang, Xuewu Ding.   

Abstract

The mixed lineage leukemia 3 (MLL3), a member of the mixed lineage leukemia (MLL) family, has been reported to be mutated in multiple cancer types. However, its function in esophageal squamous cell carcinoma (ESCC) remains poorly understood. Here, we found that the expression of MLL3 was downregulated in ESCC tissues. Moreover, over-expression of MLL3 in ESCC cells inhibited cell proliferation and migration, while the knockdown expression of MLL3 promoted the tumorigenicity of ESCC cells. Mechanistically, MLL3 regulated the expression of multiple growth-related and migration-related genes. Taken together, our study suggested that downregulation of MLL3 was very important in the progression of ESCC.

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Year:  2014        PMID： 25273170     DOI： 10.1007/s13277-014-2616-3

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  28 in total

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  10 in total

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