Literature DB >> 25272278

The phosphatase mechanism of bifunctional kinase/phosphatase AceK.

Shu Wang1, Qingya Shen, Guangju Chen, Jimin Zheng, Hongwei Tan, Zongchao Jia.   

Abstract

We have revealed that bifunctional AceK kinase/phosphatase utilizes a stepwise addition-elimination mechanism in its dephosphorylation reaction. This work explains how AceK enables opposite kinase and phosphatase activities with Asp477 and a single Mg(2+) ion.

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Year:  2014        PMID： 25272278     DOI： 10.1039/c4cc05375c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

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