OBJECTIVE: To investigate the association between anemia during pregnancy and subsequent future maternal cardiovascular morbidity and mortality. METHODS: A retrospective cohort study was conducted, comparing women with and without anemia during pregnancy. Deliveries occurred during 1988-1998 and had followed for more than a decade. Incidence of long-term cardiovascular morbidity was compared between the two groups. RESULTS: During the study period, 47 657 deliveries met the inclusion criteria; of these 12 362 (25.9%) occurred in women with anemia at least once during their pregnancies. Anemia of pregnancy was noted as a risk factor for long-term complex cardiovascular events (OR = 1.6, 95% CI 1-2.8, p = 0.04). Using a Cox multivariable regression model, controlling for ethnicity and maternal age, anemia was found to be an independent risk factor for long-term maternal cardiovascular hospitalization (OR for total hospitalizations = 1.2, 95% CI 1.1-1.4, p < 0.001). CONCLUSIONS: Anemia of pregnancy is an independent risk factor for long-term cardiovascular morbidity in a follow-up period of more than a decade.
OBJECTIVE: To investigate the association between anemia during pregnancy and subsequent future maternal cardiovascular morbidity and mortality. METHODS: A retrospective cohort study was conducted, comparing women with and without anemia during pregnancy. Deliveries occurred during 1988-1998 and had followed for more than a decade. Incidence of long-term cardiovascular morbidity was compared between the two groups. RESULTS: During the study period, 47 657 deliveries met the inclusion criteria; of these 12 362 (25.9%) occurred in women with anemia at least once during their pregnancies. Anemia of pregnancy was noted as a risk factor for long-term complex cardiovascular events (OR = 1.6, 95% CI 1-2.8, p = 0.04). Using a Cox multivariable regression model, controlling for ethnicity and maternal age, anemia was found to be an independent risk factor for long-term maternal cardiovascular hospitalization (OR for total hospitalizations = 1.2, 95% CI 1.1-1.4, p < 0.001). CONCLUSIONS:Anemia of pregnancy is an independent risk factor for long-term cardiovascular morbidity in a follow-up period of more than a decade.
Authors: Gad Hatem; Line Hjort; Olof Asplund; Daniel T R Minja; Omari Abdul Msemo; Sofie Lykke Møller; Thomas Lavstsen; Louise Groth-Grunnet; John P A Lusingu; Ola Hansson; Dirk Lund Christensen; Allan A Vaag; Isabella Artner; Thor Theander; Leif Groop; Christentze Schmiegelow; Ib Christian Bygbjerg; Rashmi B Prasad Journal: J Clin Endocrinol Metab Date: 2022-04-19 Impact factor: 6.134