Karin Åkesson1,2, Lena Hanberger3, Ulf Samuelsson3. 1. Department of Pediatrics, Ryhov County Hospital, Jönköping, Sweden. 2. Futurum - Academy for Health and Care, Jönköping County Council and Jönköping Academy for improvement of Health and Welfare, Jönköping University, Jönköping, Sweden. 3. Department of Clinical and Experimental Medicine, Division of Pediatrics and Diabetes. Research Center, Linköping University Hospital, Linköping, Sweden.
Abstract
OBJECTIVE: To explore the relationship between certain clinical variables and metabolic HbA1c at diagnosis correlated to HbA1c at follow-up (p < 0.001). There was a clear gender difference regarding HbA1c. Girls had higher values both at diagnosis and at follow-up (p < 0.001). Girls also had lower BMI and pH at diagnosis than boys (p < 0.001). In contrast, girls with the highest body mass index (BMI) at follow-up had higher mean HbA1c at follow-up in 2010 (p < 0.001). Having a mother and/or a father with high BMI implied higher HbA1c at diagnosis (p < 0.003). CONCLUSIONS: HbA1c at diagnosis seems to predict metabolic control years later. There is a gender difference at diagnosis as female patients have higher HbA1c than males at diagnosis as well as at follow up. As metabolic control is very much correlated to complications there is a need to early identify patients at risk of poor metabolic control. Even though we do not know whether a high HbA1c level is mainly due to severity of the disease or to behavioral patterns, new ways to treat and support these children, especially girls, are needed.
OBJECTIVE: To explore the relationship between certain clinical variables and metabolic HbA1c at diagnosis correlated to HbA1c at follow-up (p < 0.001). There was a clear gender difference regarding HbA1c. Girls had higher values both at diagnosis and at follow-up (p < 0.001). Girls also had lower BMI and pH at diagnosis than boys (p < 0.001). In contrast, girls with the highest body mass index (BMI) at follow-up had higher mean HbA1c at follow-up in 2010 (p < 0.001). Having a mother and/or a father with high BMI implied higher HbA1c at diagnosis (p < 0.003). CONCLUSIONS: HbA1c at diagnosis seems to predict metabolic control years later. There is a gender difference at diagnosis as female patients have higher HbA1c than males at diagnosis as well as at follow up. As metabolic control is very much correlated to complications there is a need to early identify patients at risk of poor metabolic control. Even though we do not know whether a high HbA1c level is mainly due to severity of the disease or to behavioral patterns, new ways to treat and support these children, especially girls, are needed.
Authors: Josephine Haas; Martina Persson; Anna Lena Brorsson; Eva Hagström Toft; Anna Lindholm Olinder Journal: Trials Date: 2017-11-24 Impact factor: 2.279
Authors: Amal R Khanolkar; Rakesh Amin; David Taylor-Robinson; Russell M Viner; Justin Warner; Evelien F Gevers; Terence Stephenson Journal: BMJ Open Diabetes Res Care Date: 2017-08-07
Authors: Amal R Khanolkar; Rakesh Amin; David Taylor-Robinson; Russell M Viner; Justin Warner; Evelien F Gevers; Terence Stephenson Journal: Int J Environ Res Public Health Date: 2017-12-25 Impact factor: 3.390
Authors: Jacqueline Rodriguez-Stanley; Samuele Zilioli; April Idalski Carcone; Richard B Slatcher; Deborah A Ellis Journal: Psychol Health Date: 2021-08-04
Authors: Veena Mazarello Paes; Jessica K Barrett; David B Dunger; Evelien F Gevers; David C Taylor-Robinson; Russell M Viner; Terence J Stephenson Journal: Pediatr Diabetes Date: 2019-12-17 Impact factor: 4.866
Authors: Anna R Kahkoska; Christina M Shay; Jamie Crandell; Dana Dabelea; Giuseppina Imperatore; Jean M Lawrence; Angela D Liese; Cate Pihoker; Beth A Reboussin; Shivani Agarwal; Janet A Tooze; Lynne E Wagenknecht; Victor W Zhong; Elizabeth J Mayer-Davis Journal: JAMA Netw Open Date: 2018-09-07