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Literature DB >> 25269460

Androprostamines A and B, the new anti-prostate cancer agents produced by Streptomyces sp. MK932-CF8.

Yohko Yamazaki¹, Tetsuya Someno¹, Masayuki Igarashi², Naoko Kinoshita², Masaki Hatano², Manabu Kawada¹, Isao Momose¹, Akio Nomoto³.

Abstract

Androgen receptor (AR) is a validated target in all clinical states of prostate cancer. Androprostamines A and B, the new inhibitors of androgen receptor, were isolated from Streptomyces sp. MK932-CF8. Their structures were determined by the spectroscopic analysis, degradation studies and synthesis. Androprostamines showed potent inhibitory effect against androgen-dependent growth of human prostate cancer cells without cytotoxicity and repressed the androgen-induced expression of AR-regulated genes.

Entities: Chemical Disease Species

Mesh：

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Year: 2014 PMID： 25269460 DOI： 10.1038/ja.2014.135

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

18 in total

1. Resormycin, a novel herbicidal and antifungal antibiotic produced by a strain of Streptomyces platensis. I. Taxonomy, production, isolation and biological properties.

Authors: M Igarashi; N Kinoshita; T Ikeda; M Kameda; M Hamada; T Takeuchi
Journal: J Antibiot (Tokyo) Date: 1997-12 Impact factor: 2.649

Review 2. Basic science aspects of prostate cancer.

Authors: T J Dorkin; D E Neal
Journal: Semin Cancer Biol Date: 1997-02 Impact factor: 15.707

3. Cancer statistics, 2010.

Authors: Ahmedin Jemal; Rebecca Siegel; Jiaquan Xu; Elizabeth Ward
Journal: CA Cancer J Clin Date: 2010-07-07 Impact factor: 508.702

4. Resormycin, a novel herbicidal and antifungal antibiotic produced by a strain of Streptomyces platensis. II. Structure elucidation of resormycin.

Authors: M Igarashi; H Nakamura; H Naganawa; T Takeuchi
Journal: J Antibiot (Tokyo) Date: 1997-12 Impact factor: 2.649

Review 5. Molecular genetics of prostate cancer: new prospects for old challenges.

Authors: Michael M Shen; Cory Abate-Shen
Journal: Genes Dev Date: 2010-09-15 Impact factor: 11.361

6. Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer.

Authors: P Koivisto; J Kononen; C Palmberg; T Tammela; E Hyytinen; J Isola; J Trapman; K Cleutjens; A Noordzij; T Visakorpi; O P Kallioniemi
Journal: Cancer Res Date: 1997-01-15 Impact factor: 12.701

Androprostamines A and B, the new anti-prostate cancer agents produced by Streptomyces sp. MK932-CF8.

1. Resormycin, a novel herbicidal and antifungal antibiotic produced by a strain of Streptomyces platensis. I. Taxonomy, production, isolation and biological properties.

Review 2. Basic science aspects of prostate cancer.

3. Cancer statistics, 2010.

4. Resormycin, a novel herbicidal and antifungal antibiotic produced by a strain of Streptomyces platensis. II. Structure elucidation of resormycin.

Review 5. Molecular genetics of prostate cancer: new prospects for old challenges.

6. Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer.

Review 7. Androgen receptor antagonists in castration-resistant prostate cancer.

8. Cancer statistics, 2009.

9. Molecular determinants of resistance to antiandrogen therapy.

Review 1. Endophytic bacteria: a new source of bioactive compounds.