H-X Cui1, J-Y Xu, M-Q Li. 1. Department of General Surgery, Xuzhou Center Hospital, Xuzhou, Jiangsu, China. cuihx2009@126.com.
Abstract
OBJECTIVE: To investigate the efficacy of the treatment of severe acute pancreatitis (SAP) complicated by acute respiratory distress syndrome (ARDS) using continuous renal replacement therapy (CRRT) by evaluating the effect of CRRT on respiratory and circulatory function as well as serum cytokines level. PATIENTS AND METHODS: Fifty four randomly selected patients with confirmed SAP complicated by ARDS after being admitted to intensive care unit (ICU) within 72 hr of onset were included in the study. Patients received mechanical respiratory support and CRRT. Arterial blood gas analysis was conducted and serum cytokine levels, including tumor necrosis factor alpha (TNF-α), interleukin 4 (IL-4) and interleukin 6 (IL-6), as well as C reactive protein (CRP) were evaluated respectively both before and 6h, 12h, and 24h after CRRT therapy. Peak inspiratory pressure and pulmonary compliance were also recorded. RESULTS: Arterial oxygen tension (PaO2), oxygenation index (OI) as well as dynamic pulmonary compliance were all elevated significantly, whereas peak inspiratory pressure significantly decreased at 6h, 12h and 24h after CRRT respectively; serum cytokine level and CRP significantly decreased (p < 0.05). CONCLUSIONS: CRRT can effectively reduce the level of inflammatory mediators, and improve respiratory and circulatory function.
OBJECTIVE: To investigate the efficacy of the treatment of severe acute pancreatitis (SAP) complicated by acute respiratory distress syndrome (ARDS) using continuous renal replacement therapy (CRRT) by evaluating the effect of CRRT on respiratory and circulatory function as well as serum cytokines level. PATIENTS AND METHODS: Fifty four randomly selected patients with confirmed SAP complicated by ARDS after being admitted to intensive care unit (ICU) within 72 hr of onset were included in the study. Patients received mechanical respiratory support and CRRT. Arterial blood gas analysis was conducted and serum cytokine levels, including tumor necrosis factor alpha (TNF-α), interleukin 4 (IL-4) and interleukin 6 (IL-6), as well as C reactive protein (CRP) were evaluated respectively both before and 6h, 12h, and 24h after CRRT therapy. Peak inspiratory pressure and pulmonary compliance were also recorded. RESULTS: Arterial oxygen tension (PaO2), oxygenation index (OI) as well as dynamic pulmonary compliance were all elevated significantly, whereas peak inspiratory pressure significantly decreased at 6h, 12h and 24h after CRRT respectively; serum cytokine level and CRP significantly decreased (p < 0.05). CONCLUSIONS: CRRT can effectively reduce the level of inflammatory mediators, and improve respiratory and circulatory function.
Authors: Nelli Farkas; Lilla Hanák; Alexandra Mikó; Judit Bajor; Patrícia Sarlós; József Czimmer; Áron Vincze; Szilárd Gódi; Dániel Pécsi; Péter Varjú; Katalin Márta; Péter Jenő Hegyi; Bálint Erőss; Zsolt Szakács; Tamás Takács; László Czakó; Balázs Németh; Dóra Illés; Balázs Kui; Erika Darvasi; Ferenc Izbéki; Adrienn Halász; Veronika Dunás-Varga; László Gajdán; József Hamvas; Mária Papp; Ildikó Földi; Krisztina Eszter Fehér; Márta Varga; Klára Csefkó; Imola Török; Farkas Hunor-Pál; Artautas Mickevicius; Elena Ramirez Maldonado; Ville Sallinen; János Novák; Ali Tüzün Ince; Shamil Galeev; Barnabás Bod; János Sümegi; Petr Pencik; Attila Szepes; Andrea Szentesi; Andrea Párniczky; Péter Hegyi Journal: Front Physiol Date: 2019-09-04 Impact factor: 4.566