Literature DB >> 25267656

Structure of nicastrin unveils secrets of γ-secretase.

David M Bolduc1, Michael S Wolfe2.   

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Year:  2014        PMID： 25267656      PMCID： PMC4205669          DOI： 10.1073/pnas.1416637111

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


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  15 in total

Review 1.  Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective.

Authors:  Rudolph E Tanzi; Lars Bertram
Journal:  Cell       Date:  2005-02-25       Impact factor: 41.582

Review 2.  Presenilin: running with scissors in the membrane.

Authors:  Dennis J Selkoe; Michael S Wolfe
Journal:  Cell       Date:  2007-10-19       Impact factor: 41.582

3.  Crystal structure of the γ-secretase component nicastrin.

Authors:  Tian Xie; Chuangye Yan; Rui Zhou; Yanyu Zhao; Linfeng Sun; Guanghui Yang; Peilong Lu; Dan Ma; Yigong Shi
Journal:  Proc Natl Acad Sci U S A       Date:  2014-09-02       Impact factor: 11.205

4.  Nicastrin functions as a gamma-secretase-substrate receptor.

Authors:  Sanjiv Shah; Sheu-Fen Lee; Katsuhiko Tabuchi; Yi-Heng Hao; Cong Yu; Quincey LaPlant; Haydn Ball; Charles E Dann; Thomas Südhof; Gang Yu
Journal:  Cell       Date:  2005-08-12       Impact factor: 41.582

5.  Activation and intrinsic gamma-secretase activity of presenilin 1.

Authors:  Kwangwook Ahn; Christopher C Shelton; Yuan Tian; Xulun Zhang; M Lane Gilchrist; Sangram S Sisodia; Yue-Ming Li
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-29       Impact factor: 11.205

6.  The role of presenilin cofactors in the gamma-secretase complex.

Authors:  Nobumasa Takasugi; Taisuke Tomita; Ikuo Hayashi; Makiko Tsuruoka; Manabu Niimura; Yasuko Takahashi; Gopal Thinakaran; Takeshi Iwatsubo
Journal:  Nature       Date:  2003-03-16       Impact factor: 49.962

7.  Dictyostelium possesses highly diverged presenilin/gamma-secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/gamma-secretase complex.

Authors:  Vanessa C McMains; Michael Myre; Lisa Kreppel; Alan R Kimmel
Journal:  Dis Model Mech       Date:  2010-08-10       Impact factor: 5.758

Review 8.  Intramembrane proteolysis.

Authors:  Michael S Wolfe
Journal:  Chem Rev       Date:  2009-04       Impact factor: 60.622

9.  Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity.

Authors:  Lucía Chávez-Gutiérrez; Alexandra Tolia; Elke Maes; Tong Li; Philip C Wong; Bart de Strooper
Journal:  J Biol Chem       Date:  2008-05-23       Impact factor: 5.157

10.  Glu-333 of nicastrin directly participates in gamma-secretase activity.

Authors:  Daniel R Dries; Sanjiv Shah; Yu-Hong Han; Cong Yu; Sophie Yu; Mark S Shearman; Gang Yu
Journal:  J Biol Chem       Date:  2009-09-03       Impact factor: 5.157
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  4 in total

1.  Membrane-associated epithelial cell adhesion molecule is slowly cleaved by γ-secretase prior to efficient proteasomal degradation of its intracellular domain.

Authors:  Yuanchi Huang; Anna Chanou; Gisela Kranz; Min Pan; Vera Kohlbauer; Andreas Ettinger; Olivier Gires
Journal:  J Biol Chem       Date:  2018-12-31       Impact factor: 5.157

Review 2.  The γ-secretase complex: from structure to function.

Authors:  Xian Zhang; Yanfang Li; Huaxi Xu; Yun-Wu Zhang
Journal:  Front Cell Neurosci       Date:  2014-12-11       Impact factor: 5.505

3.  High-efficient production and biophysical characterisation of nicastrin and its interaction with APPC100.

Authors:  Kun Yu; Ge Yang; Jörg Labahn
Journal:  Sci Rep       Date:  2017-03-09       Impact factor: 4.379

4.  Characterizing the structural ensemble of γ-secretase using a multiscale molecular dynamics approach.

Authors:  Rodrigo Aguayo-Ortiz; Cecilia Chávez-García; John E Straub; Laura Dominguez
Journal:  Chem Sci       Date:  2017-06-05       Impact factor: 9.825
  4 in total

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