Literature DB >> 25266780

Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase.

Anna M Rydzik1, Jürgen Brem1, Weston B Struwe1, Grazyna T Kochan2, Justin L P Benesch1, Christopher J Schofield3.   

Abstract

γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate and Fe(II) dependent oxygenase that catalyses an essential step during carnitine biosynthesis in animals. BBOX is inhibited by ejection of structural zinc by a set of selenium containing analogues. Previous structural analyses indicated that an undisrupted N-terminal zinc binding domain of BBOX is required for catalysis. Ebselen is a relatively potent BBOX inhibitor, an observation which may in part reflect its cardioprotective properties.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  2-Oxoglutarate dependent oxygenase; Carnitine; Ebselen; Zinc ejection; γ-Butyrobetaine hydroxylase

Mesh：

Substances：

Year:  2014        PMID： 25266780     DOI： 10.1016/j.bmcl.2014.09.035

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

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Authors:  Mariska de Munnik; Christopher T Lohans; Pauline A Lang; Gareth W Langley; Tika R Malla; Anthony Tumber; Christopher J Schofield; Jürgen Brem
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  4 in total

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