Wei Zhang1, Jianguo Wan2, Kejian Qian1, Xiaoqing Liu3, Zuke Xiao4, Jian Sun5, Zhenguo Zeng1, Qi Wang6, Jinxiang Zhang2, Guanghui Jiang2, Cheng Nie1, Rong Jiang1, Chengzhi Ding1, Ran Li7, Peter Horby8, Zhancheng Gao9. 1. Nanchang University First Affiliated Hospital, Nanchang, Jiangxi 330006, China. 2. Nanchang First Hospital, Nanchang, Jiangxi 330008, China. 3. Jiangxi Province Center for Disease Control and Prevention, Nanchang, Jiangxi 330038, China. 4. Jiangxi Provincial People's Hospital, Nanchang, Jiangxi 330006, China. 5. Nanchang University Fourth Affiliated Hospital, Nanchang, Jiangxi 330003, China. 6. Chinese Center for Disease Control and Prevention, Beijing 102206, China. 7. Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China. 8. Oxford University Clinical Research Unit -Wellcome Trust Major Overseas Programme, Hanoi, Vietnam. 9. Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China. Email: zcgao@bjmu.edu.cn.
Abstract
BACKGROUND: Novel influenza A viruses of avian-origin may be the precursors of pandemic strains. This descriptive study aims to introduce a novel avian-origin influenza A (H10N8) virus which can infect humans and cause severe diseases. METHODS: Collecting clinical data of three cases of human infection with a novel reassortment avian influenza A (H10N8) virus in Nanchang, Jiangxi Province, China. RESULTS: Three cases of human infection with a new reassortment avian influenza A(H10N8) virus were described, of which two were fatal cases, and one was severe case. These cases presented with severe pneumonia that progressed to acute respiratory distress syndrome (ARDS) and intractable respiratory failure. CONCLUSION: This novel reassortment avian influenza A (H10N8) virus in China resulted in fatal human infections, and should be added to concerns in clinical practice.
BACKGROUND: Novel influenza A viruses of avian-origin may be the precursors of pandemic strains. This descriptive study aims to introduce a novel avian-origin influenza A (H10N8) virus which can infect humans and cause severe diseases. METHODS: Collecting clinical data of three cases of humaninfection with a novel reassortment avian influenza A (H10N8) virus in Nanchang, Jiangxi Province, China. RESULTS: Three cases of humaninfection with a new reassortment avian influenza A(H10N8) virus were described, of which two were fatal cases, and one was severe case. These cases presented with severe pneumonia that progressed to acute respiratory distress syndrome (ARDS) and intractable respiratory failure. CONCLUSION: This novel reassortment avian influenza A (H10N8) virus in China resulted in fatal human infections, and should be added to concerns in clinical practice.
Authors: Dennis Christensen; Jan P Christensen; Karen S Korsholm; Louise K Isling; Karin Erneholm; Allan R Thomsen; Peter Andersen Journal: Front Immunol Date: 2018-01-08 Impact factor: 7.561
Authors: Kapil Bahl; Joe J Senn; Olga Yuzhakov; Alex Bulychev; Luis A Brito; Kimberly J Hassett; Michael E Laska; Mike Smith; Örn Almarsson; James Thompson; Amilcar Mick Ribeiro; Mike Watson; Tal Zaks; Giuseppe Ciaramella Journal: Mol Ther Date: 2017-04-27 Impact factor: 12.910