Literature DB >> 25265346

The phenomenon of multi-drug resistance in the treatment of malignant tumors.

S V Vtorushin1, K Y Khristenko1, M V Zavyalova1, V M Perelmuter1, N V Litviakov2, E V Denisov3, A Y Dulesova1, N V Cherdyntseva1.   

Abstract

Multi-drug resistance (MDR) is a condition when there is broad cross-resistance of cells to various agents which are different in structure and effect. Modern perceptions on mechanisms of MDR development in malignant tumors have been considered, in particular, in tre-ating breast cancer. Physiological functions and contribution to MDR development of ABC-transporter protein families have been described. The role of activation of glutathione system enzymes and apoptosis-regulating proteins in MDR formation has been shown.

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Year:  2014        PMID： 25265346

Source DB:  PubMed          Journal:  Exp Oncol        ISSN： 1812-9269


  17 in total

Review 1.  Breast cancer: molecular mechanisms of underlying resistance and therapeutic approaches.

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Journal:  Am J Cancer Res       Date:  2022-07-15       Impact factor: 5.942

2.  Targeting the chromatin remodeling enzyme BRG1 increases the efficacy of chemotherapy drugs in breast cancer cells.

Authors:  Qiong Wu; Soni Sharma; Hang Cui; Scott E LeBlanc; Hong Zhang; Rohini Muthuswami; Jeffrey A Nickerson; Anthony N Imbalzano
Journal:  Oncotarget       Date:  2016-05-10

3.  Galectin-1 knockdown improves drug sensitivity of breast cancer by reducing P-glycoprotein expression through inhibiting the Raf-1/AP-1 signaling pathway.

Authors:  Fang Wang; Pengwei Lv; Yuanting Gu; Lin Li; Xin Ge; Guangcheng Guo
Journal:  Oncotarget       Date:  2017-04-11

4.  Inhibition of paclitaxel resistance and apoptosis induction by cucurbitacin B in ovarian carcinoma cells.

Authors:  Yingchun Qu; Peifang Cong; Chengjiang Lin; Yihui Deng; Jesse Li-Ling; Meixia Zhang
Journal:  Oncol Lett       Date:  2017-05-10       Impact factor: 2.967

5.  Salvianolic acid B reverses multidrug resistance in nude mice bearing human colon cancer stem cells.

Authors:  Piaoting Guo; Jianchao Wang; Wencang Gao; Xia Liu; Shaofei Wu; Boshun Wan; Lei Xu; Yanhua Li
Journal:  Mol Med Rep       Date:  2018-05-29       Impact factor: 2.952

6.  Furanodiene Induces Extrinsic and Intrinsic Apoptosis in Doxorubicin-Resistant MCF-7 Breast Cancer Cells via NF-κB-Independent Mechanism.

Authors:  Zhang-Feng Zhong; Hai-Bing Yu; Chun-Ming Wang; Wen-An Qiang; Sheng-Peng Wang; Jin-Ming Zhang; Hua Yu; Liao Cui; Tie Wu; De-Qiang Li; Yi-Tao Wang
Journal:  Front Pharmacol       Date:  2017-09-14       Impact factor: 5.810

Review 7.  LncRNA as a multifunctional regulator in cancer multi-drug resistance.

Authors:  Jiaying He; Shaomi Zhu; Xin Liang; Qinxiu Zhang; Xiaohong Luo; Chi Liu; Linjiang Song
Journal:  Mol Biol Rep       Date:  2021-07-31       Impact factor: 2.316

8.  A 20(S)-protopanoxadiol derivative overcomes multi-drug resistance by antagonizing ATP-binding cassette subfamily B member 1 transporter function.

Authors:  Gang Chen; Junhua Liu; Wantao Chen; Qin Xu; Meng Xiao; Lihong Hu; Li Mao; Xu Wang
Journal:  Oncotarget       Date:  2016-02-23

9.  Phosphoproteome profiling reveals critical role of JAK-STAT signaling in maintaining chemoresistance in breast cancer.

Authors:  Augusto S Nascimento; Luisa L Peres; Alessandra V S Fari; Renato Milani; Rodrigo A Silva; Celio Jr da Costa Fernandes; Maikel P Peppelenbosch; Carmen V Ferreira-Halder; Willian F Zambuzzi
Journal:  Oncotarget       Date:  2017-10-10

10.  Scutellarin Inhibits Proliferation, Invasion, and Tumorigenicity in Human Breast Cancer Cells by Regulating HIPPO-YAP Signaling Pathway.

Authors:  Lengchen Hou; Lei Chen; Lin Fang
Journal:  Med Sci Monit       Date:  2017-10-28
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