| Literature DB >> 25264196 |
Quan Huang1, Zhengyu Jiang1, Tong Meng1, Huabin Yin1, Jing Wang1, Wei Wan1, Mo Cheng1, Wangjun Yan1, Tielong Liu1, Dianwen Song1, Haiyan Chen2, Zhipeng Wu1, Wei Xu1, Zhenxi Li3, Wang Zhou4, Jianru Xiao5.
Abstract
RunX2 has been identified to crucially regulate the osteolysis in giant cell tumor of bone. MiR-30a is an intronic miRNA identified as tumor suppressor, but little is known about its role in giant tumor cell of bone. In our research, we reported miR-30a was down-regulated in GCT whereas RunX2 was highly expressed. Further research proved that miR-30a can regulate the expression of RunX2 by binding to its 3'-UTR, which influence the osteoclast differentiation and osteolysis formation. Thus, these results suggest that miR-30a could directly target RunX2 and participate in osteolysis in GCT.Entities:
Keywords: Giant cell tumor of bone; Osteoclast differentiation; RunX2; miR-30a-5p
Mesh：
Substances：
Year: 2014 PMID： 25264196 DOI： 10.1016/j.bbrc.2014.09.076
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575