Literature DB >> 25264104

Entry of Bombyx mori nucleopolyhedrovirus into BmN cells by cholesterol-dependent macropinocytic endocytosis.

Jinshan Huang1, Bifang Hao2, Chen Cheng3, Fei Liang3, Xingjia Shen2, Xiaowen Cheng4.   

Abstract

Bombyx mori nucleopolyhedrovirus (BmNPV) is a serious viral pathogen of silkworm, and no drug or specific protection against BmNPV infection is available at present time. Although functions of most BmNPV genes were depicted in recent years, knowledge on the mechanism of BmNPV entry into insect cells is still limited. Here BmNPV cell entry mechanism is investigated by different endocytic inhibitor application and subcellular analysis. Results indicated that BmNPV enters BmN cells by clathrin-independent macropinocytic endocytosis, which is mediated by cholesterol in a dose-dependent manner, and cholesterol replenishment rescued the BmNPV infection partially.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  BmNPV; Cholesterol; Endocytosis; Macropinocytosis

Mesh：

Substances：

Year:  2014        PMID： 25264104     DOI： 10.1016/j.bbrc.2014.09.073

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  11 in total

1.  18 Additional Amino Acids of the Signal Peptide of the Bombyx mori Nucleopolyhedrovirus GP64 Activates Immunoglobulin Binding Protein (BiP) Expression by RNA-seq Analysis.

Authors:  Na Liu; Jinshan Huang; Lin Liu; Frank Boadi; Yanhui Song; Zhongjian Guo; Xingjia Shen; Bifang Hao
Journal:  Curr Microbiol       Date:  2021-01-02       Impact factor: 2.188

2.  Identification of endoplasmic-reticulum-associated proteins involved in Bombyx mori nucleopolyhedrovirus entry by RNA-seq analysis.

Authors:  Bifang Hao; Chenya Li; Charles Amanze; Jinshan Huang
Journal:  Arch Virol       Date:  2022-02-24       Impact factor: 2.574

3.  Identification and Characterization of Genes Related to Resistance of Autographa californica Nucleopolyhedrovirus Infection in Bombyx mori.

Authors:  Yunhui Kong; Lingling Sun; Yaling Tang; Jiashuang Li; Sheng Qin; Muwang Li
Journal:  Insects       Date:  2022-05-06       Impact factor: 3.139

4.  Transport Via Macropinocytic Vesicles is Crucial for Productive Infection with Bombyx Mori Nucleopolyhedrovirus.

Authors:  Jinshan Huang; Chenya Li; Xudong Tang; Lin Liu; Wenbin Nan; Xingjia Shen; Bifang Hao
Journal:  Viruses       Date:  2019-07-20       Impact factor: 5.048

5.  Methyl-Beta-Cyclodextrin-Induced Macropinocytosis Results in Increased Infection of Sf21 Cells by Bombyx Mori Nucleopolyhedrovirus.

Authors:  Jinshan Huang; Chenya Li; Fengxiu Fan; Na Liu; Frank Boadi; Xingjia Shen; Bifang Hao
Journal:  Viruses       Date:  2019-10-11       Impact factor: 5.048

6.  Efficient Expression and Processing of Ebola Virus Glycoprotein Induces Morphological Changes in BmN Cells but Cannot Rescue Deficiency of Bombyx Mori Nucleopolyhedrovirus GP64.

Authors:  Jinshan Huang; Na Liu; Fanbo Xu; Ellen Ayepa; Charles Amanze; Luping Sun; Yaqin Shen; Miao Yang; Shuwen Yang; Xingjia Shen; Bifang Hao
Journal:  Viruses       Date:  2019-11-15       Impact factor: 5.048

Review 7.  Advances in the Arms Race Between Silkworm and Baculovirus.

Authors:  Liang Jiang; Marian R Goldsmith; Qingyou Xia
Journal:  Front Immunol       Date:  2021-02-09       Impact factor: 7.561

8.  Two Cholesterol Recognition Amino Acid Consensus Motifs of GP64 with Uncleaved Signal Peptide Are Required for Bombyx mori Nucleopolyhedrovirus Infection.

Authors:  Bifang Hao; Wenbin Nan; Ying Xu; Lin Liu; Na Liu; Jinshan Huang
Journal:  Microbiol Spectr       Date:  2021-12-22

9.  The NPC Families Mediate BmNPV Entry.

Authors:  Youpeng Fan; Jialing Bao; Xiaoyu Fu; Pengfei Wu; Jingya Chen; Yan Huang; Junhong Wei; Guoqing Pan; Chunfeng Li; Zeyang Zhou
Journal:  Microbiol Spectr       Date:  2022-07-05

Review 10.  A comparative review of viral entry and attachment during large and giant dsDNA virus infections.

Authors:  Haitham Sobhy
Journal:  Arch Virol       Date:  2017-09-02       Impact factor: 2.574
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