Literature DB >> 25264019

Structure of pravastatin and its complex with sodium dodecyl sulfate micelles studied by NMR spectroscopy.

L F Galiullina1, I Z Rakhmatullin, E A Klochkova, A V Aganov, V V Klochkov.   

Abstract

The aim of this work was to study the mechanisms of interaction between pravastatin and cell membranes using model membranes (sodium dodecyl sulfate micelles) by nuclear magnetic resonance spectroscopy methods. On the basis of the nuclear magnetic resonance experiments, it was established that pravastatin can form intermolecular complexes with sodium dodecyl sulfate micelles by the interaction of its hydrophilic groups with the polar surface of the micelle. Conformational features of pravastatin molecule were also studied.
Copyright © 2014 John Wiley & Sons, Ltd.

Entities:  

Keywords:  NMR spectroscopy; biophysical models; complexation; micelle; nuclear overhauser effect; pravastatin; sodium dodecyl sulfate; surfactants

Mesh：

Substances：

Year:  2014        PMID： 25264019     DOI： 10.1002/mrc.4146

Source DB:  PubMed          Journal:  Magn Reson Chem        ISSN： 0749-1581            Impact factor:   2.447


  3 in total

1.  Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of BODIPY FL-Labeled Thioterpenoid.

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Journal:  Bioengineering (Basel)       Date:  2022-05-12

2.  Sulfur-Containing Monoterpenoids as Potential Antithrombotic Drugs: Research in the Molecular Mechanism of Coagulation Activity Using Pinanyl Sulfoxide as an Example.

Authors:  Liliya E Nikitina; Sergei V Kiselev; Valeriya A Startseva; Andrei V Bodrov; Zulfiya R Azizova; Olga T Shipina; Inna V Fedyunina; Sergei V Boichuk; Olga A Lodochnikova; Vladimir V Klochkov; Leisan F Galiullina; Aliya V Khaliullina
Journal:  Front Pharmacol       Date:  2018-02-19       Impact factor: 5.810

3.  Molecular Recognition of Imidazole Derivatives by Co(III)-Porphyrinsin Phosphate Buffer (pH = 7.4) and Cetylpyridinium Chloride Containing Solutions.

Authors:  Galina M Mamardashvili; Elena Yu Kaigorodova; Olga A Dmitrieva; Oscar I Koifman; Nugzar Zh Mamardashvili
Journal:  Molecules       Date:  2021-02-06       Impact factor: 4.411
  3 in total

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