Paul L Wood1, Michaela D Filiou2, David M Otte3, Andreas Zimmer3, Christoph W Turck2. 1. Metabolomics Unit, Department of Physiology and Pharmacology, DeBusk College of Osteopathic Medicine, Lincoln Memorial University, 6965 Cumberland Gap Pkwy., Harrogate, TN 37752, USA. Electronic address: paul.wood@lmunet.edu. 2. Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, Munich D-80804, Germany. 3. Institute of Molecular Psychiatry, University of Bonn, Sigmund Freud Str. 25, Bonn D-53127, Germany.
Abstract
BACKGROUND: Abnormal structural/functional connectivity has been proposed to underlie the pathophysiology of schizophrenia. However, the biochemical basis of abnormal connectivity remains undefined. METHODS: We undertook a shotgun lipidomic analysis of over 700 lipids across 26 lipid subclasses in the frontal cortex of schizophrenia subjects and hippocampus of G72/G30 transgenic mice. RESULTS: We demonstrate that glycosphingolipids and choline plasmalogens, structural lipid pools in myelin, are significantly elevated in the frontal cortex obtained from patients suffering from schizophrenia and the hippocampus of G72/G30 transgenic mice. CONCLUSIONS: Our data suggest that structural lipid alterations in oligodendrocyte glycosynapses are responsible for dysconnectivity in schizophrenia and that increased expression of G72 protein may play a role in the development of abnormal glycosynapses.
BACKGROUND: Abnormal structural/functional connectivity has been proposed to underlie the pathophysiology of schizophrenia. However, the biochemical basis of abnormal connectivity remains undefined. METHODS: We undertook a shotgun lipidomic analysis of over 700 lipids across 26 lipid subclasses in the frontal cortex of schizophrenia subjects and hippocampus of G72/G30transgenic mice. RESULTS: We demonstrate that glycosphingolipids and choline plasmalogens, structural lipid pools in myelin, are significantly elevated in the frontal cortex obtained from patients suffering from schizophrenia and the hippocampus of G72/G30transgenic mice. CONCLUSIONS: Our data suggest that structural lipid alterations in oligodendrocyte glycosynapses are responsible for dysconnectivity in schizophrenia and that increased expression of G72 protein may play a role in the development of abnormal glycosynapses.
Authors: Colm M P O'Tuathaigh; Naina Mathur; Matthew J O'Callaghan; Lynsey MacIntyre; Richard Harvey; Donna Lai; John L Waddington; Benjamin S Pickard; David G Watson; Paula M Moran Journal: Schizophr Bull Date: 2017-09-01 Impact factor: 9.306
Authors: Susanne Sales; Juergen Graessler; Sara Ciucci; Rania Al-Atrib; Terhi Vihervaara; Kai Schuhmann; Dimple Kauhanen; Marko Sysi-Aho; Stefan R Bornstein; Marc Bickle; Carlo V Cannistraci; Kim Ekroos; Andrej Shevchenko Journal: Sci Rep Date: 2016-06-14 Impact factor: 4.379