Omer Gunes1, Emre Tascilar2, Erdim Sertoglu3, Ahmet Tas4, Muhittin A Serdar5, Güven Kaya2, Huseyin Kayadibi6, Okan Ozcan2. 1. Agri Military Hospital, Department of Pediatrics, Agri, Turkey. Electronic address: dromergunes@gmail.com. 2. Gulhane School of Medicine, Department of Pediatrics, Ankara, Turkey. 3. Ankara Mevki Military Hospital, Anittepe Dispensary, Ankara, Turkey. 4. Gulhane School of Medicine, Department of Medical Biochemistry, Ankara, Turkey. 5. Acıbadem University School Of Medicine, Department of Medical Biochemistry, Istanbul, Turkey. 6. Adana Military Hospital, Department of Medical Biochemistry, Adana, Turkey.
Abstract
BACKGROUND/ OBJECTIVE: Cytokines released from the adipose tissue and fatty acids (FAs) derived from lipolysis or uptake of fats go in to competition with glucose to be uptaken from the liver leads to insulin resistance (IR). We aimed to show the associations among serum lipid profile, FA compositions and IR. METHODS: Anthropometrical measurements, biochemical parameters and erythrocyte membrane (EM) FA levels of 95 obese adolescents (41 with IR) and 40 healthy controls were compared. RESULTS: LDL-C, fasting insulin levels, HOMA-IR were significantly higher and HDL-C levels were significantly lower in obese patients than in controls (p=0.013, p<0.001, p<0.001 and p<0.001, respectively). EM C 24:0, C 16:1 ω7 and C 22:1 ω9 FA levels were significantly higher, while C 20:5 ω3 (EPA) levels were significantly lower in obese subjects than in controls (p<0.001, p=0.018, p<0.001, p=0.043 and p<0.001, respectively). Moreover, when obese subjects divided into two groups according to the presence of IR; EM C 16:1 ω7 levels were still significantly higher and EPA levels were still significantly lower in both obese subjects with and without IR compared to controls (p<0.001 for both). CONCLUSION: Saturated FA intake should be decreased because of its role in the development of obesity and IR, and ω-3 group FA intake should be increased.
BACKGROUND/ OBJECTIVE: Cytokines released from the adipose tissue and fatty acids (FAs) derived from lipolysis or uptake of fats go in to competition with glucose to be uptaken from the liver leads to insulin resistance (IR). We aimed to show the associations among serum lipid profile, FA compositions and IR. METHODS: Anthropometrical measurements, biochemical parameters and erythrocyte membrane (EM) FA levels of 95 obese adolescents (41 with IR) and 40 healthy controls were compared. RESULTS: LDL-C, fasting insulin levels, HOMA-IR were significantly higher and HDL-C levels were significantly lower in obesepatients than in controls (p=0.013, p<0.001, p<0.001 and p<0.001, respectively). EM C 24:0, C 16:1 ω7 and C 22:1 ω9 FA levels were significantly higher, while C 20:5 ω3 (EPA) levels were significantly lower in obese subjects than in controls (p<0.001, p=0.018, p<0.001, p=0.043 and p<0.001, respectively). Moreover, when obese subjects divided into two groups according to the presence of IR; EM C 16:1 ω7 levels were still significantly higher and EPA levels were still significantly lower in both obese subjects with and without IR compared to controls (p<0.001 for both). CONCLUSION: Saturated FA intake should be decreased because of its role in the development of obesity and IR, and ω-3 group FA intake should be increased.
Authors: Pamela A Nono Nankam; Paul J van Jaarsveld; Elin Chorell; Melony C Fortuin-de Smidt; Kevin Adams; Matthias Blüher; Tommy Olsson; Amy E Mendham; Julia H Goedecke Journal: Nutrients Date: 2020-05-31 Impact factor: 5.717