Sergio Cadoni1, Stefano Sanna2, Paolo Gallittu1, Mariangela Argiolas2, Viviana Fanari2, Maria L Porcedda2, Matteo Erriu3, Felix W Leung4. 1. Digestive Endoscopy Unit, S. Barbara Hospital, Iglesias, Italy. 2. Digestive Endoscopy Unit, N. S. di Bonaria Hospital, San Gavino Monreale, Italy. 3. Department of Surgical Sciences, University of Cagliari, Cagliari, Italy. 4. Sepulveda Ambulatory Care Center, Veterans Affairs Greater Los Angeles Healthcare System, North Hills, California, USA; David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California, USA.
Abstract
BACKGROUND: A recent American Society for Gastrointestinal Endoscopy Technology Status Evaluation Report recommended comparative studies of water-aided colonoscopy methods to refine the optimal insertion technique. OBJECTIVE:Air insufflation (AI), water immersion (WI), and water exchange (WE) were compared head-to-head to test the hypothesis that WE produces the least insertion pain. DESIGN: Patient-blinded, prospective, randomized, controlled trials. SETTING:Two community hospitals in Italy. PATIENTS: First-time diagnostic or screening colonoscopy in unsedated patients with the option of on-demand sedation. INTERVENTION: Colonoscopy with AI, WI, or WE. MAIN OUTCOME MEASUREMENTS: Real-time maximum insertion pain (0 = none, 10 = worst). To avoid interventional bias, the timing of recording was at the discretion of the nurse assistant. Adjunct measures were implemented to ensure patient perception of minimal discomfort. Recalled pain and patients' guess of insertion methods were recorded after colonoscopy. RESULTS: Results were merged for 576 randomized patients. Correct patient guesses lower than 33% confirmed adequate blinding. Significant correlation (Pearson coefficient 0.6, P < .0005) between real-time and recalled pain provided internal validation of the former as the primary outcome. Real-time pain (95% confidence interval [CI]: AI, 4.1 [3.7-4.5]; WI, 3.5 [3.0-3.9]; and WE, 2.5 [2.2-2.9] [P < .0005] was the lowest in the WE group. The proportions of patients completing unsedated colonoscopy based on the assigned methods were significantly different (WE, 74.7% vs WI, 62.4%; P = .009; vs AI, 65.3%; P = .04). WE required the least implementation of adjunct maneuvers. LIMITATIONS: Unblinded colonoscopists. CONCLUSION: The current findings with an internally validated primary outcome in adequately blinded patients support the hypothesis that WE is superior to WI in attenuating real-time insertion pain and enhancing completion of unsedated colonoscopy.
RCT Entities:
BACKGROUND: A recent American Society for Gastrointestinal Endoscopy Technology Status Evaluation Report recommended comparative studies of water-aided colonoscopy methods to refine the optimal insertion technique. OBJECTIVE: Air insufflation (AI), water immersion (WI), and water exchange (WE) were compared head-to-head to test the hypothesis that WE produces the least insertion pain. DESIGN:Patient-blinded, prospective, randomized, controlled trials. SETTING: Two community hospitals in Italy. PATIENTS: First-time diagnostic or screening colonoscopy in unsedated patients with the option of on-demand sedation. INTERVENTION: Colonoscopy with AI, WI, or WE. MAIN OUTCOME MEASUREMENTS: Real-time maximum insertion pain (0 = none, 10 = worst). To avoid interventional bias, the timing of recording was at the discretion of the nurse assistant. Adjunct measures were implemented to ensure patient perception of minimal discomfort. Recalled pain and patients' guess of insertion methods were recorded after colonoscopy. RESULTS: Results were merged for 576 randomized patients. Correct patient guesses lower than 33% confirmed adequate blinding. Significant correlation (Pearson coefficient 0.6, P < .0005) between real-time and recalled pain provided internal validation of the former as the primary outcome. Real-time pain (95% confidence interval [CI]: AI, 4.1 [3.7-4.5]; WI, 3.5 [3.0-3.9]; and WE, 2.5 [2.2-2.9] [P < .0005] was the lowest in the WE group. The proportions of patients completing unsedated colonoscopy based on the assigned methods were significantly different (WE, 74.7% vs WI, 62.4%; P = .009; vs AI, 65.3%; P = .04). WE required the least implementation of adjunct maneuvers. LIMITATIONS: Unblinded colonoscopists. CONCLUSION: The current findings with an internally validated primary outcome in adequately blinded patients support the hypothesis that WE is superior to WI in attenuating real-time insertion pain and enhancing completion of unsedated colonoscopy.
Authors: Sergio Cadoni; Mauro Liggi; Premysl Falt; Stefano Sanna; Mariangela Argiolas; Viviana Fanari; Paolo Gallittu; Donatella Mura; Maria L Porcedda; Vit Smajstrla; Matteo Erriu; Felix W Leung Journal: World J Gastrointest Endosc Date: 2016-01-25