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Literature DB >> 2526195

Induction of Fc epsilon R2/CD23 on human epidermal Langerhans cells by human recombinant interleukin 4 and gamma interferon.

T Bieber¹, A Rieger, C Neuchrist, J C Prinz, E P Rieber, G Boltz-Nitulescu, O Scheiner, D Kraft, J Ring, G Stingl.

Abstract

Human rIL-4 and human rIFN-gamma are able to induce the expression of the low affinity receptor for IgE (Fc epsilon R2/CD23) on normal human epidermal Langerhans cells, whereas IL-2 and PMA have no effect. A synergistic effect is observed when both cytokines are combined. These receptors are synthesized de novo by the LC since cycloheximide completely inhibits the appearance of Fc epsilon R2/CD23. Fc epsilon R2/CD23+ LC may have a major role in the pathogenesis of atopic eczema, as well as in the regulation of IgE synthesis.

Entities: Chemical Disease Gene Species

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Year: 1989 PMID： 2526195 PMCID： PMC2189378 DOI： 10.1084/jem.170.1.309

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

12 in total

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27 in total

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Journal: J Neurosci Date: 1999-05-01 Impact factor: 6.167