PURPOSE: The results from the published studies on the association between LEPR genetic polymorphisms and cancer risk are conflicting. The common LEPR Q223R genetic polymorphism has been reported to be functional and may contribute to genetic susceptibility to cancer. However, the association between LEPR Q223R genetic polymorphism and cancer risk remains inconclusive. METHODS: To better understand the role of LEPR Q223R genetic polymorphism in global cancer, we conducted this comprehensive meta-analysis encompassing 9139 cases and 11282 controls. RESULTS: Overall, the LEPR Q223R genetic polymorphism did not significantly affect the risk of cancer. In the stratified analysis, there was no significant association of LEPR Q223R variant with breast cancer, colorectal cancer and non-Hodgkin's lymphoma (NHL) under any models. Moreover, significantly increased risks were found in Asian and African in all genetic models tested. When stratified by study design, no significantly increased susceptibility to cancer was found among any studies. No significantly differences in sample size in cases were found among genotypes. CONCLUSIONS: These findings suggested lack of association between LEPR Q223R polymorphisms and cancer susceptibility, but the LEPR Q223R genetic polymorphism may increase the susceptibility to cancers in Asian and African individuals. Large, well designed epidemiological studies are needed to validate our findings.
PURPOSE: The results from the published studies on the association between LEPR genetic polymorphisms and cancer risk are conflicting. The common LEPR Q223R genetic polymorphism has been reported to be functional and may contribute to genetic susceptibility to cancer. However, the association between LEPR Q223R genetic polymorphism and cancer risk remains inconclusive. METHODS: To better understand the role of LEPR Q223R genetic polymorphism in global cancer, we conducted this comprehensive meta-analysis encompassing 9139 cases and 11282 controls. RESULTS: Overall, the LEPR Q223R genetic polymorphism did not significantly affect the risk of cancer. In the stratified analysis, there was no significant association of LEPR Q223R variant with breast cancer, colorectal cancer and non-Hodgkin's lymphoma (NHL) under any models. Moreover, significantly increased risks were found in Asian and African in all genetic models tested. When stratified by study design, no significantly increased susceptibility to cancer was found among any studies. No significantly differences in sample size in cases were found among genotypes. CONCLUSIONS: These findings suggested lack of association between LEPR Q223R polymorphisms and cancer susceptibility, but the LEPR Q223R genetic polymorphism may increase the susceptibility to cancers in Asian and African individuals. Large, well designed epidemiological studies are needed to validate our findings.
Authors: Arjun Gupta; Yehuda Herman; Colby Ayers; Muhammad S Beg; Susan G Lakoski; Shuaib M Abdullah; David H Johnson; Ian J Neeland Journal: PLoS One Date: 2016-09-16 Impact factor: 3.240
Authors: Jan Bieńkiewicz; Hanna Romanowicz; Miłosz Wilczyński; Grzegorz Jabłoński; Anna Stepowicz; Anna Obłękowska; Andrzej Malinowski; Beata Smolarz Journal: BMC Cancer Date: 2021-08-16 Impact factor: 4.430