Lukas L Imbach1, Michael Sommerauer2, Kaspar Leuenberger3, Sebastian R Schreglmann2, Oliver Maier2, Mechtild Uhl2, Roger Gassert3, Christian R Baumann2. 1. Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland. Electronic address: lukas.imbach@usz.ch. 2. Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland. 3. Rehabilitation Engineering Laboratory, Department of Health Sciences and Technology, ETH Zurich, CH-8092, Switzerland.
Abstract
BACKGROUND: Diagnosis and treatment of tremor are largely based on clinical assessment. Whereas in some patients tremor may respond to dopaminergic treatment, in general l-Dopa response to tremor varies considerably. The aim of this study was to predict l-Dopa response by accelerometry. METHODS: We included 60 tremor patients and measured harmonic oscillations by accelerometry. In addition to neurological assessment, we performed l-Dopa challenge tests and the individual tremor response was compared to the amount of harmonic oscillations. RESULTS: We found a strong correlation between harmonic oscillations and clinical l-Dopa response. Similarly, harmonic oscillations were significantly greater in patients with subjective tremor reduction upon l-Dopa administration. CONCLUSIONS: We conclude that harmonic oscillations are a measure for l-Dopa response to tremor irrespective of the underlying disease. Because of the observational character of the study, any causal relation remains speculative. Nevertheless, we propose a novel, non-invasive approach to predict l-Dopa response in tremor patients.
BACKGROUND: Diagnosis and treatment of tremor are largely based on clinical assessment. Whereas in some patientstremor may respond to dopaminergic treatment, in general l-Dopa response to tremor varies considerably. The aim of this study was to predict l-Dopa response by accelerometry. METHODS: We included 60 tremorpatients and measured harmonic oscillations by accelerometry. In addition to neurological assessment, we performed l-Dopa challenge tests and the individual tremor response was compared to the amount of harmonic oscillations. RESULTS: We found a strong correlation between harmonic oscillations and clinical l-Dopa response. Similarly, harmonic oscillations were significantly greater in patients with subjective tremor reduction upon l-Dopa administration. CONCLUSIONS: We conclude that harmonic oscillations are a measure for l-Dopa response to tremor irrespective of the underlying disease. Because of the observational character of the study, any causal relation remains speculative. Nevertheless, we propose a novel, non-invasive approach to predict l-Dopa response in tremorpatients.
Authors: Sujitha Mahendran; Oliver Bichsel; Roger Gassert; Christian R Baumann; Lukas L Imbach; Daniel Waldvogel Journal: Clin Park Relat Disord Date: 2022-05-21
Authors: Daniel Rodríguez-Martín; Joan Cabestany; Carlos Pérez-López; Marti Pie; Joan Calvet; Albert Samà; Chiara Capra; Andreu Català; Alejandro Rodríguez-Molinero Journal: Front Neurol Date: 2022-06-02 Impact factor: 4.086
Authors: Dayle Rüegge; Sujitha Mahendran; Lennart H Stieglitz; Markus F Oertel; Roger Gassert; Olivier Lambercy; Christian R Baumann; Lukas L Imbach Journal: Clin Park Relat Disord Date: 2020-08-05