P Wang1, M H Li2, G G Liu3, J Thumboo4, N Luo5. 1. Saw Swee Hock School of Public Health, National University of Singapore, 16 Medical Drive, Block MD3, Singapore, 117597, Singapore. 2. Department of Pharmaceutical Health Services Research, University of Maryland, Baltimore, MD, USA. 3. National School of Development, Peking University, Beijing, China. 4. Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore. 5. Saw Swee Hock School of Public Health, National University of Singapore, 16 Medical Drive, Block MD3, Singapore, 117597, Singapore. nan_luo@nuhs.edu.sg.
Abstract
BACKGROUND: Little is known about whether health-state preferences differ among Chinese populations. This study compared the preference values for EQ-5D-5L health states between mainland Chinese and Singaporean Chinese. METHODS: The preference values for ten EQ-5D-5L health states were elicited from general population samples of mainland Chinese and Singaporeans. In computer-assisted self-interviews, each participant completed five time trade-off (TTO) tasks to value five different EQ-5D-5L health states. The difference in TTO values between mainland Chinese and Singaporean Chinese was examined using random-effects linear regression and logistic regression models. RESULTS: A total of 194 eligible mainland Chinese and 145 eligible Singaporean Chinese provided data for this study. All ten health states considered, the mean TTO value was 0.18 for Singaporean Chinese and 0.35 for mainland Chinese, with the unadjusted and adjusted difference [95% confidence interval (CI)] being -0.17 (-0.28, -0.07) and -0.16 (-0.27, -0.05). Singaporean Chinese had substantially lower TTO values than mainland Chinese for states with severe or extreme problems, with the adjusted difference being -0.30 (95% CI -0.42, -0.17). On the other hand, Singaporean Chinese and mainland Chinese had similar TTO values for states with mild or moderate problems, with the adjusted (95% CI) difference being 0.04 (-0.07, 0.15). Logistic regression analysis showed that Singaporean Chinese were more likely to rate health states with severe or extreme problems as worse than death compared to mainland Chinese. CONCLUSIONS: Mainland Chinese and Singaporean Chinese have different preferences for EQ-5D-5L health states, supporting the development of local value sets for the EQ-5D-5L instrument for the two populations.
BACKGROUND: Little is known about whether health-state preferences differ among Chinese populations. This study compared the preference values for EQ-5D-5L health states between mainland Chinese and Singaporean Chinese. METHODS: The preference values for ten EQ-5D-5L health states were elicited from general population samples of mainland Chinese and Singaporeans. In computer-assisted self-interviews, each participant completed five time trade-off (TTO) tasks to value five different EQ-5D-5L health states. The difference in TTO values between mainland Chinese and Singaporean Chinese was examined using random-effects linear regression and logistic regression models. RESULTS: A total of 194 eligible mainland Chinese and 145 eligible Singaporean Chinese provided data for this study. All ten health states considered, the mean TTO value was 0.18 for Singaporean Chinese and 0.35 for mainland Chinese, with the unadjusted and adjusted difference [95% confidence interval (CI)] being -0.17 (-0.28, -0.07) and -0.16 (-0.27, -0.05). Singaporean Chinese had substantially lower TTO values than mainland Chinese for states with severe or extreme problems, with the adjusted difference being -0.30 (95% CI -0.42, -0.17). On the other hand, Singaporean Chinese and mainland Chinese had similar TTO values for states with mild or moderate problems, with the adjusted (95% CI) difference being 0.04 (-0.07, 0.15). Logistic regression analysis showed that Singaporean Chinese were more likely to rate health states with severe or extreme problems as worse than death compared to mainland Chinese. CONCLUSIONS: Mainland Chinese and Singaporean Chinese have different preferences for EQ-5D-5L health states, supporting the development of local value sets for the EQ-5D-5L instrument for the two populations.
Entities:
Keywords:
EQ-5D-5L; Health-state preferences; Mainland Chinese; Singaporean Chinese; Time trade-off