Literature DB >> 25257084

NLRC4 gets out of control.

Hanif Javanmard Khameneh1, Alessandra Mortellaro1.   

Abstract

The NLRC4 inflammasome mediates the rapid release of proinflammatory cytokines in response to various microbial stimuli, but its role in the pathology of human diseases remains unknown. Two new studies now report gain-of-function mutations in the NLRC4 gene that cosegregate with distinct autoinflammatory syndromes in affected families.

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Year:  2014        PMID： 25257084     DOI： 10.1038/ng.3100

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  14 in total

1.  Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1.

Authors:  J L Poyet; S M Srinivasula; M Tnani; M Razmara; T Fernandes-Alnemri; E S Alnemri
Journal:  J Biol Chem       Date:  2001-06-04       Impact factor: 5.157

2.  Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages.

Authors:  Luigi Franchi; Amal Amer; Mathilde Body-Malapel; Thirumala-Devi Kanneganti; Nesrin Ozören; Rajesh Jagirdar; Naohiro Inohara; Peter Vandenabeele; John Bertin; Anthony Coyle; Ethan P Grant; Gabriel Núñez
Journal:  Nat Immunol       Date:  2006-04-30       Impact factor: 25.606

3.  Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome.

Authors:  Edward A Miao; Dat P Mao; Natalya Yudkovsky; Richard Bonneau; Cynthia G Lorang; Sarah E Warren; Irina A Leaf; Alan Aderem
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-01       Impact factor: 11.205

4.  Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf.

Authors:  Sanjeev Mariathasan; Kim Newton; Denise M Monack; Domagoj Vucic; Dorothy M French; Wyne P Lee; Meron Roose-Girma; Sharon Erickson; Vishva M Dixit
Journal:  Nature       Date:  2004-06-09       Impact factor: 49.962

5.  Phosphorylation of NLRC4 is critical for inflammasome activation.

Authors:  Yan Qu; Shahram Misaghi; Anita Izrael-Tomasevic; Kim Newton; Laurie L Gilmour; Mohamed Lamkanfi; Salina Louie; Nobuhiko Kayagaki; Jinfeng Liu; László Kömüves; James E Cupp; David Arnott; Denise Monack; Vishva M Dixit
Journal:  Nature       Date:  2012-08-12       Impact factor: 49.962

6.  Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity.

Authors:  Eric M Kofoed; Russell E Vance
Journal:  Nature       Date:  2011-08-28       Impact factor: 49.962

Review 7.  Emerging Concepts about NAIP/NLRC4 Inflammasomes.

Authors:  Silvia Lucena Lage; Carla Longo; Laura Migliari Branco; Thaís Boccia da Costa; Carina de Lima Buzzo; Karina Ramalho Bortoluci
Journal:  Front Immunol       Date:  2014-07-02       Impact factor: 7.561

Review 8.  The Central Role of Anti-IL-1 Blockade in the Treatment of Monogenic and Multi-Factorial Autoinflammatory Diseases.

Authors:  Silvia Federici; Alberto Martini; Marco Gattorno
Journal:  Front Immunol       Date:  2013-10-31       Impact factor: 7.561

9.  An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome.

Authors:  Scott W Canna; Adriana A de Jesus; Sushanth Gouni; Stephen R Brooks; Bernadette Marrero; Yin Liu; Michael A DiMattia; Kristien J M Zaal; Gina A Montealegre Sanchez; Hanna Kim; Dawn Chapelle; Nicole Plass; Yan Huang; Alejandro V Villarino; Angelique Biancotto; Thomas A Fleisher; Joseph A Duncan; John J O'Shea; Susanne Benseler; Alexei Grom; Zuoming Deng; Ronald M Laxer; Raphaela Goldbach-Mansky
Journal:  Nat Genet       Date:  2014-09-14       Impact factor: 38.330

10.  Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation.

Authors:  Neil Romberg; Khatoun Al Moussawi; Carol Nelson-Williams; Amy L Stiegler; Erin Loring; Murim Choi; John Overton; Eric Meffre; Mustafa K Khokha; Anita J Huttner; Brian West; Nikolai A Podoltsev; Titus J Boggon; Barbara I Kazmierczak; Richard P Lifton
Journal:  Nat Genet       Date:  2014-09-14       Impact factor: 38.330
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  3 in total

1.  Recombinant Salmonella expressing SspH2-EscI fusion protein limits its colonization in mice.

Authors:  Maozhi Hu; Weixin Zhao; Wei Gao; Wenhua Li; Chuang Meng; Qiuxiang Yan; Yuyang Wang; Xiaohui Zhou; Shizhong Geng; Zhiming Pan; Guiyou Cui; Xinan Jiao
Journal:  BMC Immunol       Date:  2017-05-03       Impact factor: 3.615

2.  Immunization with recombinant Salmonella expressing SspH2-EscI protects mice against wild type Salmonella infection.

Authors:  Maozhi Hu; Weixin Zhao; Hongying Li; Jie Gu; Qiuxiang Yan; Xiaohui Zhou; Zhiming Pan; Guiyou Cui; Xinan Jiao
Journal:  BMC Vet Res       Date:  2018-03-09       Impact factor: 2.741

3.  NLRC4 gene silencing-dependent blockade of NOD-like receptor pathway inhibits inflammation, reduces proliferation and increases apoptosis of dendritic cells in mice with septic shock.

Authors:  Shi-Sheng Wang; Chun-Song Yan; Jun-Ming Luo
Journal:  Aging (Albany NY)       Date:  2021-01-06       Impact factor: 5.682
  3 in total

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