| Literature DB >> 25256549 |
Mitali Dewan1, Biplab Bhowmick1, Gunjan Sarkar1, Dipak Rana2, Mrinal Kanti Bain3, Manas Bhowmik4, Dipankar Chattopadhyay5.
Abstract
The effect of weight average molecular weight (Mw) of methyl cellulose (MC) on the gelation behavior of Poloxamer 407 (PM) and in vitro release of Ketorolac Tromethamine (KT) from different ophthalmic formulations based on PM is examined. A drop of gelation temperature of PM is observed using MC of various M(w) by test tube tilting method, UV-vis spectroscopy, viscometry and rheometry. It is also observed that the viscosity and gel strength of all the formulations are increased with the increase in Mw of MC. PM with highest Mw of MC provides best drug release property among all the formulations. It is evident from this investigation that there is a distinct effect of M(w) of MC on the gelation behavior of PM as well as on the drug release profile of KT from PM-MC based ophthalmic formulations.Entities:
Keywords: Gelation behavior; In vitro drug release; Methyl cellulose; Molecular weight effect; Rheological property
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Year: 2014 PMID： 25256549 DOI： 10.1016/j.ijbiomac.2014.09.021
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953