Cécilia Samieri1, Cécile Proust-Lima2, Maria M Glymour3, Olivia I Okereke4, Rebecca E Amariglio5, Reisa A Sperling5, Dorene M Rentz5, Francine Grodstein6. 1. Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; INSERM, Centre INSERM U897-Epidémiologie-Biostatistiques, Bordeaux, France; Univ. Bordeaux, Centre INSERM U897-Epidémiologie-Biostatistiques, Bordeaux, France. Electronic address: cecilia.samieri@channing.harvard.edu. 2. INSERM, Centre INSERM U897-Epidémiologie-Biostatistiques, Bordeaux, France; Univ. Bordeaux, Centre INSERM U897-Epidémiologie-Biostatistiques, Bordeaux, France. 3. Department of Social & Behavioral Sciences, Harvard School of Public Health, Boston, MA, USA; Department of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA. 4. Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA; Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA. 5. Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. 6. Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Abstract
BACKGROUND: Subjective cognitive concerns may represent a simple method to assess likelihood of memory decline among apolipoprotein E (APOE) ε4 carriers. METHODS: We examined the relationship of self-reported subjective cognitive concerns, using seven specific cognitive concerns, with memory and memory decline over 6 years among APOE ε4 carriers and non-carriers from the Nurses' Health Study. RESULTS: In both groups, increasing subjective cognitive concern score predicted worse baseline memory and faster rates of subsequent memory decline, after adjustment for age, education and depression. The relation with baseline memory appeared statistically stronger in APOE ε4 carriers (P-interaction = 0.03). For memory decline, mean differences in slopes of episodic memory (95% CI) for 4 to 7 versus no concern = -0.05 (-0.10, 0.01) standard units in APOE ε4 carriers, and -0.04 (-0.08, -0.01) standard units in non-carriers. CONCLUSIONS: APOE ε4 carriers with self-assessed cognitive concerns appear to have worse memory, and possibly accelerated memory decline.
BACKGROUND: Subjective cognitive concerns may represent a simple method to assess likelihood of memory decline among apolipoprotein E (APOE) ε4 carriers. METHODS: We examined the relationship of self-reported subjective cognitive concerns, using seven specific cognitive concerns, with memory and memory decline over 6 years among APOE ε4 carriers and non-carriers from the Nurses' Health Study. RESULTS: In both groups, increasing subjective cognitive concern score predicted worse baseline memory and faster rates of subsequent memory decline, after adjustment for age, education and depression. The relation with baseline memory appeared statistically stronger in APOE ε4 carriers (P-interaction = 0.03). For memory decline, mean differences in slopes of episodic memory (95% CI) for 4 to 7 versus no concern = -0.05 (-0.10, 0.01) standard units in APOE ε4 carriers, and -0.04 (-0.08, -0.01) standard units in non-carriers. CONCLUSIONS:APOE ε4 carriers with self-assessed cognitive concerns appear to have worse memory, and possibly accelerated memory decline.
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