Ling Li1, Linong Ji2, Xiaohui Guo3, Qiuhe Ji4, Weijun Gu5, Xinyue Zhi1, Xing Li6, Hongyu Kuang7, Benli Su8, Jinhua Yan9, Xilin Yang10. 1. Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China. 2. Department of Endocrinology and metabolism, Peking University People's Hospital, Beijing, China. 3. Department of Endocrinology, Peking University First Hospital, Beijing, China. 4. Department of Endocrinology, Xijing Hospital affiliated to 4th Military Medical University, Xi'an, China. 5. Department of Endocrinology, Chinese PLA General Hospital, Beijing, China. 6. Department of Endocrinology, The Second Hospital of Shanxi Medical University, Taiyuan, China. 7. Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China. 8. Department of Endocrinology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China. 9. Department of Endocrinology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. 10. Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China. Electronic address: yxl@hotmail.com.
Abstract
AIMS: This study aimed to investigate the impact of early-onset diabetes on the risk of microvascular diseases in Chinese with type 2 diabetes mellitus (T2DM). METHODS: A cross sectional survey of 29,442 patients with T2DM in 77 tertiary hospitals in China was conducted in 2011. Early-onset diabetes was defined as diagnosis of diabetes before 40years of age. Microvascular complications and risk factors were documented. Prevalence of microvascular disease was standardized to the Chinese population in 2010. Logistic regression analysis was performed to obtain odds ratios (OR) for early versus late onset of T2DM. RESULTS: A total of 1,303 (4.4%) patients had nephropathy, 2,137 (7.3%) had retinopathy and 3,012 (10.2%) had either of them. Early-onset diabetes greatly increased the prevalence of microvascular diseases compared with late-onset diabetes (nephropathy: 5.1% vs. 1.5%; retinopathy: 7.1% vs. 2.7%; either: 9.7% vs. 3.6%), especially among patients from 45 to 59years of age. After adjusting for age and sex, patients with early-onset T2DM were at 1.69-fold (95% CI 1.46-1.95) higher risk of microvascular diseases than those with late-onset T2DM. However, this was not significant after adjusting for traditional risk factors and disease duration (p=0.162). CONCLUSION: Chinese patients with early-onset T2DM are at a marked increased risk of microvascular diseases.
AIMS: This study aimed to investigate the impact of early-onset diabetes on the risk of microvascular diseases in Chinese with type 2 diabetes mellitus (T2DM). METHODS: A cross sectional survey of 29,442 patients with T2DM in 77 tertiary hospitals in China was conducted in 2011. Early-onset diabetes was defined as diagnosis of diabetes before 40years of age. Microvascular complications and risk factors were documented. Prevalence of microvascular disease was standardized to the Chinese population in 2010. Logistic regression analysis was performed to obtain odds ratios (OR) for early versus late onset of T2DM. RESULTS: A total of 1,303 (4.4%) patients had nephropathy, 2,137 (7.3%) had retinopathy and 3,012 (10.2%) had either of them. Early-onset diabetes greatly increased the prevalence of microvascular diseases compared with late-onset diabetes (nephropathy: 5.1% vs. 1.5%; retinopathy: 7.1% vs. 2.7%; either: 9.7% vs. 3.6%), especially among patients from 45 to 59years of age. After adjusting for age and sex, patients with early-onset T2DM were at 1.69-fold (95% CI 1.46-1.95) higher risk of microvascular diseases than those with late-onset T2DM. However, this was not significant after adjusting for traditional risk factors and disease duration (p=0.162). CONCLUSION: Chinese patients with early-onset T2DM are at a marked increased risk of microvascular diseases.
Authors: Rayne R Lim; DeAna G Grant; T Dylan Olver; Jaume Padilla; Alana M Czajkowski; Teagan R Schnurbusch; Rajiv R Mohan; Dean P Hainsworth; Eric M Walters; Shyam S Chaurasia Journal: Invest Ophthalmol Vis Sci Date: 2018-05-01 Impact factor: 4.799