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Literature DB >> 25255303

Preliminary dosimetric evaluation of (166)Ho-TTHMP for human based on biodistribution data in rats.

Hassan Yousefnia¹, Samaneh Zolghadri², Amir Reza Jalilian¹, Mojtaba Tajik³, Mohammad Ghannadi-Maragheh¹.

Abstract

In this work, the absorbed dose to each organ of human for (166)Ho-TTHMP was evaluated based on biodistribution studies in rats by a RADAR method and was compared with (166)Ho-DOTMP as the only clinically used Ho-166 bone marrow ablative agent. The highest absorbed dose for this complex is observed in red marrow with 0.922mGy/MBq. The results show that (166)Ho-TTHMP has considerable characteristics compared to (166)Ho-DOTMP and can be a good candidate for bone marrow ablation in patients with multiple myeloma.

Entities: Disease Species

Keywords: (166)Ho-TTHMP; Bone marrow ablation; Internal dosimetry; RADAR

Mesh：

Substances：

Year: 2014 PMID： 25255303 DOI： 10.1016/j.apradiso.2014.08.017

Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513

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Cited

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