Literature DB >> 25255164

Prevalence of chromosomally integrated human herpesvirus 6 in patients with human herpesvirus 6-central nervous system dysfunction.

Joshua A Hill1, Ruth Hall Sedlak2, Danielle M Zerr3, Meei-Li Huang4, Cecilia Yeung5, David Myerson5, Keith R Jerome6, Michael J Boeckh7.   

Abstract

We identified 37 hematopoietic cell transplantation recipients with human herpesvirus 6 (HHV-6) central nervous system dysfunction and tested donor-recipient pairs for chromosomally integrated HHV-6 (ciHHV-6). One patient had ciHHV-6A with possible HHV-6A reactivation and encephalitis. There was no ciHHV-6 enrichment in this group, but larger studies are needed to determine if patients with ciHHV-6 are at increased risk for HHV-6-associated diseases or other complications.
Copyright © 2015 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Central nervous system (CNS); Herpesvirus (hhv-6); Integration; Transplant

Mesh：

Substances：

Year:  2014        PMID： 25255164      PMCID： PMC4438705          DOI： 10.1016/j.bbmt.2014.09.015

Source DB:  PubMed          Journal:  Biol Blood Marrow Transplant        ISSN： 1083-8791            Impact factor:   5.742


  10 in total

1.  Human herpesvirus 6 DNA levels in cerebrospinal fluid due to primary infection differ from those due to chromosomal viral integration and have implications for diagnosis of encephalitis.

Authors:  Katherine N Ward; Hoe Nam Leong; Anton D Thiruchelvam; Claire E Atkinson; Duncan A Clark
Journal:  J Clin Microbiol       Date:  2007-01-17       Impact factor: 5.948

2.  Human herpesvirus 6 can be detected in cerebrospinal fluid without associated symptoms after allogeneic hematopoietic cell transplantation.

Authors:  Joshua A Hill; Michael J Boeckh; Ruth Hall Sedlak; Keith R Jerome; Danielle M Zerr
Journal:  J Clin Virol       Date:  2014-07-12       Impact factor: 3.168

3.  Pathogenesis from the reactivation of chromosomally integrated human herpesvirus type 6: facts rather than fiction.

Authors:  Louis Flamand
Journal:  Clin Infect Dis       Date:  2014-05-06       Impact factor: 9.079

4.  The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro.

Authors:  Jesse H Arbuckle; Maria M Medveczky; Janos Luka; Stephen H Hadley; Andrea Luegmayr; Dharam Ablashi; Troy C Lund; Jakub Tolar; Kenny De Meirleir; Jose G Montoya; Anthony L Komaroff; Peter F Ambros; Peter G Medveczky
Journal:  Proc Natl Acad Sci U S A       Date:  2010-03-08       Impact factor: 11.205

5.  Severe encephalomyelitis in an immunocompetent adult with chromosomally integrated human herpesvirus 6 and clinical response to treatment with foscarnet plus ganciclovir.

Authors:  Stephanie B Troy; Brian G Blackburn; Kristen Yeom; Anna K Finley Caulfield; Munveer S Bhangoo; Jose G Montoya
Journal:  Clin Infect Dis       Date:  2008-12-15       Impact factor: 9.079

6.  Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency.

Authors:  Akifumi Endo; Ken Watanabe; Tamae Ohye; Kyoko Suzuki; Tomoyo Matsubara; Norio Shimizu; Hiroki Kurahashi; Tetsushi Yoshikawa; Harutaka Katano; Naoki Inoue; Kohsuke Imai; Masatoshi Takagi; Tomohiro Morio; Shuki Mizutani
Journal:  Clin Infect Dis       Date:  2014-05-06       Impact factor: 9.079

7.  Human herpes virus-6 DNA in cerebrospinal fluid of children undergoing therapy for acute leukaemia.

Authors:  Boris Wittekindt; Annemarie Berger; Luciana Porto; Stefan Vlaho; Hans Peter Grüttner; Martina Becker; Thomas Lehrnbecher
Journal:  Br J Haematol       Date:  2008-03-05       Impact factor: 6.998

8.  Identification of chromosomally integrated human herpesvirus 6 by droplet digital PCR.

Authors:  Ruth Hall Sedlak; Linda Cook; Meei-Li Huang; Amalia Magaret; Danielle M Zerr; Michael Boeckh; Keith R Jerome
Journal:  Clin Chem       Date:  2014-03-04       Impact factor: 8.327

9.  Variability of gB and gH genes of human herpesvirus-6 among clinical specimens.

Authors:  Abla Achour; Isabelle Malet; Frédéric Le Gal; Axelle Dehée; Agnès Gautheret-Dejean; Pascale Bonnafous; Henri Agut
Journal:  J Med Virol       Date:  2008-07       Impact factor: 2.327

Review 10.  Chromosomally integrated human herpesvirus 6: questions and answers.

Authors:  Philip E Pellett; Dharam V Ablashi; Peter F Ambros; Henri Agut; Mary T Caserta; Vincent Descamps; Louis Flamand; Agnès Gautheret-Dejean; Caroline B Hall; Rammurti T Kamble; Uwe Kuehl; Dirk Lassner; Irmeli Lautenschlager; Kristin S Loomis; Mario Luppi; Paolo Lusso; Peter G Medveczky; Jose G Montoya; Yasuko Mori; Masao Ogata; Joshua C Pritchett; Sylvie Rogez; Edward Seto; Katherine N Ward; Tetsushi Yoshikawa; Raymund R Razonable
Journal:  Rev Med Virol       Date:  2011-11-04       Impact factor: 6.989
  10 in total
  9 in total

1.  Possible reactivation of chromosomally integrated human herpesvirus 6 after treatment with histone deacetylase inhibitor.

Authors:  Ioannis Politikos; Malgorzata McMasters; Christine Bryke; David Avigan; Vassiliki A Boussiotis
Journal:  Blood Adv       Date:  2018-06-26

2.  Efficient identification of inherited chromosomally integrated human herpesvirus 6 using specimen pooling.

Authors:  Joshua A Hill; Ruth HallSedlak; Amalia Magaret; Meei-Li Huang; Danielle M Zerr; Keith R Jerome; Michael Boeckh
Journal:  J Clin Virol       Date:  2016-02-20       Impact factor: 3.168

3.  Stabilization of Telomere G-Quadruplexes Interferes with Human Herpesvirus 6A Chromosomal Integration.

Authors:  Shella Gilbert-Girard; Annie Gravel; Sara Artusi; Sara N Richter; Nina Wallaschek; Benedikt B Kaufer; Louis Flamand
Journal:  J Virol       Date:  2017-06-26       Impact factor: 5.103

Review 4.  Human herpesvirus-6 encephalitis after allogeneic hematopoietic cell transplantation: what we do and do not know.

Authors:  M Ogata; T Fukuda; T Teshima
Journal:  Bone Marrow Transplant       Date:  2015-04-27       Impact factor: 5.483

5.  Outcomes of hematopoietic cell transplantation using donors or recipients with inherited chromosomally integrated HHV-6.

Authors:  Joshua A Hill; Amalia S Magaret; Ruth Hall-Sedlak; Anna Mikhaylova; Meei-Li Huang; Brenda M Sandmaier; John A Hansen; Keith R Jerome; Danielle M Zerr; Michael Boeckh
Journal:  Blood       Date:  2017-06-08       Impact factor: 22.113

6.  Optimisation of a quantitative polymerase chain reaction-based strategy for the detection and quantification of human herpesvirus 6 DNA in patients undergoing allogeneic haematopoietic stem cell transplantation.

Authors:  Miriam Y H Ueda; Paulo G Alvarenga; Juliana M Real; Eloisa de Sá Moreira; Aripuanã Watanabe; Ana Maria Passos-Castilho; Matheus Vescovi; Yana Novis; Vanderson Rocha; Adriana Seber; Jose S R Oliveira; Celso A Rodrigues; Celso F H Granato
Journal:  Mem Inst Oswaldo Cruz       Date:  2015-06-02       Impact factor: 2.743

Review 7.  Roseolovirus-associated encephalitis in immunocompetent and immunocompromised individuals.

Authors:  Joseph Ongrádi; Dharam V Ablashi; Tetsushi Yoshikawa; Balázs Stercz; Masao Ogata
Journal:  J Neurovirol       Date:  2016-08-18       Impact factor: 2.643

8.  Guidelines from the 2017 European Conference on Infections in Leukaemia for management of HHV-6 infection in patients with hematologic malignancies and after hematopoietic stem cell transplantation.

Authors:  Katherine N Ward; Joshua A Hill; Petr Hubacek; Rafael de la Camara; Roberto Crocchiolo; Hermann Einsele; David Navarro; Christine Robin; Catherine Cordonnier; Per Ljungman
Journal:  Haematologica       Date:  2019-08-29       Impact factor: 9.941

9.  Association of Inherited Chromosomally Integrated Human Herpesvirus 6 with Neurologic Symptoms and Management after Allogeneic Hematopoietic Cell Transplantation.

Authors:  Madeleine R Heldman; Cassandra Job; Joyce Maalouf; Jessica Morris; Hu Xie; Chris Davis; Terry Stevens-Ayers; Meei-Li Huang; Keith R Jerome; Jesse R Fann; Danielle M Zerr; Michael Boeckh; Joshua A Hill
Journal:  Transplant Cell Ther       Date:  2021-06-07
  9 in total

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