Yan-Ming Zhou1, Xiao-Feng Zhang1, Lu-Peng Wu1, Cheng-Jun Sui1, Jia-Mei Yang1. 1. Yan-Ming Zhou, Lu-Peng Wu, Department of Hepato-Biliary-Pancreato-Vascular Surgery, the First Affiliated Hospital of Xiamen University, Xiamen 361003, Fujian Province, China.
Abstract
AIM: To identify risk factors contributing to the development of combined hepatocellular-cholangiocarcinoma (CHC) in China. METHODS: One hundred and twenty-six patients with CHC and 4:1 matched healthy controls were interviewed during the period from February 2000 to October 2012. Logistic regression analysis was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for each risk factor. RESULTS: Univariate analysis showed that the significant risk factors for CHC development were hepatitis B virus (HBV) infection, heavy alcohol consumption, a family history of liver cancer, and diabetes mellitus. Multivariate stepwise logistic regression analysis showed that HBV infection (OR = 19.245, 95%CI: 13.260-27.931) and heavy alcohol consumption (OR = 2.186, 95%CI: 1.070-4.466) were independent factors contributing to the development of CHC. CONCLUSION: HBV infection and heavy alcohol consumption may play a role in the development of CHC in China.
AIM: To identify risk factors contributing to the development of combined hepatocellular-cholangiocarcinoma (CHC) in China. METHODS: One hundred and twenty-six patients with CHC and 4:1 matched healthy controls were interviewed during the period from February 2000 to October 2012. Logistic regression analysis was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for each risk factor. RESULTS: Univariate analysis showed that the significant risk factors for CHC development were hepatitis B virus (HBV) infection, heavy alcohol consumption, a family history of liver cancer, and diabetes mellitus. Multivariate stepwise logistic regression analysis showed that HBV infection (OR = 19.245, 95%CI: 13.260-27.931) and heavy alcohol consumption (OR = 2.186, 95%CI: 1.070-4.466) were independent factors contributing to the development of CHC. CONCLUSION:HBV infection and heavy alcohol consumption may play a role in the development of CHC in China.
Authors: K Aoki; K Takayasu; T Kawano; Y Muramatsu; N Moriyama; F Wakao; J Yamamoto; K Shimada; T Takayama; T Kosuge Journal: Hepatology Date: 1993-11 Impact factor: 17.425
Authors: Megha Nayyar; David K Imagawa; Temel Tirkes; Aram N Demirjian; Roozbeh Houshyar; Kumar Sandrasegaran; Chaitali S Nangia; Tara Seery; P Bhargava; Joon Ii Choi; Chandana Lall Journal: Clin Mol Hepatol Date: 2014-12