James H Diaz1, Cory A Roberts2, Josh J Oliver2, Alan David Kaye3. 1. Department of Anesthesiology, Louisiana State University Health Sciences Center, New Orleans, LA ; School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA. 2. School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA. 3. Department of Anesthesiology, Louisiana State University Health Sciences Center, New Orleans, LA ; Department of Pharmacology, Louisiana State University Health Sciences Center, New Orleans, LA.
Abstract
BACKGROUND: Propofol is commonly used and well tolerated for induction of general anesthesia and is also used as a sedative in the intensive care unit. However, in rare cases, the agent may cause a fatal condition known as propofol infusion syndrome (PRIS). CASE REPORT: We present a case of PRIS that could have been fatal in a previously healthy male patient with multiple gunshot wounds. CONCLUSION: Because patients typically exhibit other potentially fatal comorbidities, PRIS is always a diagnosis of exclusion. The true incidence of PRIS remains unknown, and more objective criteria for its diagnosis need to be established.
BACKGROUND:Propofol is commonly used and well tolerated for induction of general anesthesia and is also used as a sedative in the intensive care unit. However, in rare cases, the agent may cause a fatal condition known as propofol infusion syndrome (PRIS). CASE REPORT: We present a case of PRIS that could have been fatal in a previously healthy male patient with multiple gunshot wounds. CONCLUSION: Because patients typically exhibit other potentially fatal comorbidities, PRIS is always a diagnosis of exclusion. The true incidence of PRIS remains unknown, and more objective criteria for its diagnosis need to be established.
Entities:
Keywords:
Acidosis; acute kidney injury; hypnotics and sedatives; intensive care units; propofol; rhabdomyolysis; wounds–gunshot
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