| Literature DB >> 25249532 |
O V Kotel'nikova, A P Alliluev, E Iu Drozhzhina, I S Koroleva, E A Sitnikova, A A Zinchenko, E A Gordeeva, T D Melikhova, E A Nokel', L S Zhigis, V S Zueva, O A Razguliaeva, O V Serova, E Iu Iagudaeva, L D Rumsh.
Abstract
The study of enzymatic and protective properties of recombinant IgA1 protease in active and mutant form showed that active form of IgA1 protease exhibited species - and type-specificity for mouse and human immunoglobulins. Mutant form, which did not exhibit enzymatic activity, had protective properties against meningococcal infection, induced by meningococcus serogroup A, B and C protecting the mice from lethal infection by living virulent culture of heterologous serogroups of meningococcus. Obtained results make it possible to consider IgA1 protease as a perspective preparation at the stages of development of polyvalent vaccine for protection the people from meningococcal infection of various etiology.Entities:
Keywords: IgA1 protease; enzymatic activity; immunogenicity; meningococcal vaccine; protective properties
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Year: 2014 PMID： 25249532 DOI： 10.18097/pbmc20146004479
Source DB: PubMed Journal: Biomed Khim ISSN： 2310-6905