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Literature DB >> 25249523

Protracted fecal shedding of HEV during ribavirin therapy predicts treatment relapse.

Florence Abravanel¹, Sébastien Lhomme¹, Lionel Rostaing², Nassim Kamar², Jacques Izopet¹.

Abstract

Twenty-four solid-organ-transplant recipients with chronic hepatitis E virus (HEV) infections were given ribavirin therapy for 3 months. All the patients with protracted fecal HEV shedding during treatment suffered a relapse. Monitoring HEV fecal excretion could be used to determine the optimal duration of ribavirin therapy.

Entities: Chemical Disease Species

Keywords: fecal shedding; hepatitis E virus; relapse; ribavirin therapy

Mesh：

Substances：

Year: 2014 PMID： 25249523 DOI： 10.1093/cid/ciu742

Source DB: PubMed Journal: Clin Infect Dis ISSN： 1058-4838 Impact factor: 9.079

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Cited

12 in total

Review 1. Acute and Persistent Hepatitis E Virus Genotype 3 and 4 Infection: Clinical Features, Pathogenesis, and Treatment.

Authors: Nassim Kamar; Sven Pischke
Journal: Cold Spring Harb Perspect Med Date: 2019-07-01 Impact factor: 6.915

2. Mutation in the Hepatitis E Virus Polymerase and Outcome of Ribavirin Therapy.

Authors: Sebastien Lhomme; Nassim Kamar; Florence Nicot; Jacques Ducos; Michael Bismuth; Valerie Garrigue; Joelle Petitjean-Lecherbonnier; Isabelle Ollivier; Elodie Alessandri-Gradt; Odile Goria; Heidi Barth; Peggy Perrin; Karine Saune; Martine Dubois; Romain Carcenac; Caroline Lefebvre; Nicolas Jeanne; Florence Abravanel; Jacques Izopet
Journal: Antimicrob Agents Chemother Date: 2015-12-28 Impact factor: 5.191

Protracted fecal shedding of HEV during ribavirin therapy predicts treatment relapse.

Review 1. Acute and Persistent Hepatitis E Virus Genotype 3 and 4 Infection: Clinical Features, Pathogenesis, and Treatment.

2. Mutation in the Hepatitis E Virus Polymerase and Outcome of Ribavirin Therapy.

3. Transmission of a Novel Genotype of Hepatitis E Virus from Bactrian Camels to Cynomolgus Macaques.

Review 4. Treatment of HEV Infection in Patients with a Solid-Organ Transplant and Chronic Hepatitis.

5. Plasma Hepatitis E Virus Kinetics in Solid Organ Transplant Patients Receiving Ribavirin.

6. Hepatitis E Virus Shows More Genomic Alterations in Cell Culture than In Vivo.

Review 7. Hepatitis E virus: Epidemiology, diagnosis, clinical manifestations, and treatment.

8. Hepatitis E in Transplantation.

9. Performance of a commercial assay for detecting and quantifying HEV RNA in faeces.

10. Ribavirin as a First Treatment Approach for Hepatitis E Virus Infection in Transplant Recipient Patients.