Anna K Dahl Aslan1, John M Starr2, Alison Pattie3, Ian Deary3. 1. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden Institute of Gerontology, School of Health Sciences, Box 1026, Jönköping 551 11, Sweden. 2. Geriatric Medicine, University of Edinburgh, Royal Victoria Hospital, Craigleith Road, Edinburgh EH4 2DN, UK Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK. 3. Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Abstract
BACKGROUND/ OBJECTIVES: the association between late-life obesity and late-life cognitive abilities is poorly understood. We studied the association between body mass index (BMI) and cognitive change in longitudinal population-based study spanning over the ninth decade of life. SUBJECTS/ METHODS: in total, 475 participants free of dementia at baseline from the Lothian Birth Cohort 1921 (mean age: 79.1 years, SD: 0.6) were included. Height and weight were assessed at baseline. BMI was calculated as kg/m(2). Cognitive abilities were assessed at age ∼11 years and at age ∼79, ∼83, ∼87 and ∼90 years. RESULTS: latent growth models showed that men being overweight and obese had a 0.65 (SD: 0.3) and 1.10 (SD: 0.5) points less steep decline in general cognitive ability (as measured by the Moray House Test) for each year than people of normal weight. These associations were to some extent confounded by childhood intelligence. No other association between BMI and cognition was significant, either for men or women. People who were obese in old age had significantly lower childhood intelligence (m = 43.6, SD: 1.3) than people who were normal in weight (m = 47.0, SD: 0.8) and persons being overweight (m = 47.5, SD: 0.8), F (472, 3) = 3.2, P = 0.043. CONCLUSIONS: the current study shows weak or no evidence for an association between BMI in old age and cognitive function, especially not when childhood intelligence is controlled for. Lower intelligence at the age of 11 years predicted obesity at the age of 79 years.
BACKGROUND/ OBJECTIVES: the association between late-life obesity and late-life cognitive abilities is poorly understood. We studied the association between body mass index (BMI) and cognitive change in longitudinal population-based study spanning over the ninth decade of life. SUBJECTS/ METHODS: in total, 475 participants free of dementia at baseline from the Lothian Birth Cohort 1921 (mean age: 79.1 years, SD: 0.6) were included. Height and weight were assessed at baseline. BMI was calculated as kg/m(2). Cognitive abilities were assessed at age ∼11 years and at age ∼79, ∼83, ∼87 and ∼90 years. RESULTS: latent growth models showed that men being overweight and obese had a 0.65 (SD: 0.3) and 1.10 (SD: 0.5) points less steep decline in general cognitive ability (as measured by the Moray House Test) for each year than people of normal weight. These associations were to some extent confounded by childhood intelligence. No other association between BMI and cognition was significant, either for men or women. People who were obese in old age had significantly lower childhood intelligence (m = 43.6, SD: 1.3) than people who were normal in weight (m = 47.0, SD: 0.8) and persons being overweight (m = 47.5, SD: 0.8), F (472, 3) = 3.2, P = 0.043. CONCLUSIONS: the current study shows weak or no evidence for an association between BMI in old age and cognitive function, especially not when childhood intelligence is controlled for. Lower intelligence at the age of 11 years predicted obesity at the age of 79 years.
Authors: Ana W Capuano; Robert S Wilson; Sue E Leurgans; Jeffrey D Dawson; David A Bennett; Donald Hedeker Journal: Stat Methods Med Res Date: 2016-04-28 Impact factor: 3.021
Authors: Sandra Barral; Jatinder Singh; Erin Fagan; Stephanie Cosentino; Stacy L Andersen-Toomey; Mary K Wojczynski; Mary Feitosa; Candace M Kammerer; Nicole Schupf Journal: J Gerontol A Biol Sci Med Sci Date: 2017-11-09 Impact factor: 6.053
Authors: James P Kesby; Jane J Kim; Miriam Scadeng; Gina Woods; Deborah M Kado; Jerrold M Olefsky; Dilip V Jeste; Cristian L Achim; Svetlana Semenova Journal: PLoS One Date: 2015-10-08 Impact factor: 3.240
Authors: S M Kumpulainen; K Heinonen; M K Salonen; S Andersson; D Wolke; E Kajantie; J G Eriksson; K Raikkonen Journal: Nutr Diabetes Date: 2016-08-15 Impact factor: 5.097