| Literature DB >> 25248627 |
Andrew K Cheung1, Terry Fei Fan Ng, Kelly M Lager, David P Alt, Eric Delwart, Roman M Pogranichniy.
Abstract
Metagenomic analysis of fecal samples collected from diarrheal swine detected sequences encoding a replication initiator protein (Rep). The genomes of ten novel single-stranded DNA viruses were determined, and they exhibited a similar genome organization. The two putative open reading frames (ORFs) encoding Rep and the capsid protein are bidirectionally transcribed and separated by two intergenic regions. Stem-loop structure(s) typical of genomes that undergo the rolling-circle DNA replication mechanism were observed. Phylogenetically, these ten genomes are in a monophyletic clade with the previously described porcine stool-associated virus (PoSCV) but are divergent enough to be further classified into to six distinct virus clades.Entities:
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Year: 2014 PMID: 25248627 DOI: 10.1007/s00705-014-2234-9
Source DB: PubMed Journal: Arch Virol ISSN: 0304-8608 Impact factor: 2.574