Literature DB >> 25246515

Shigella hacks host immune responses by reprogramming the host epigenome.

Hiroshi Ashida1, Chihiro Sasakawa2.   

Abstract

Bacterial pathogens alter host transcriptional programs to promote infection. Shigella OspF is an essential virulence protein with a unique phosphothreonine lyase activity. A new study in The EMBO Journal (Harouz et al, 2014) reveals a novel function of OspF: targeting of heterochromatin protein 1γ (HP1γ) and downregulation of a subset of immune genes. These results illustrate how bacterial pathogens exploit epigenetic modifications to counteract host immune responses.

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Year:  2014        PMID： 25246515      PMCID： PMC4282568          DOI： 10.15252/embj.201489934

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  8 in total

Review 1.  The changing faces of HP1: From heterochromatin formation and gene silencing to euchromatic gene expression: HP1 acts as a positive regulator of transcription.

Authors:  So Hee Kwon; Jerry L Workman
Journal:  Bioessays       Date:  2011-01-27       Impact factor: 4.345

2.  A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection.

Authors:  Haig A Eskandarian; Francis Impens; Marie-Anne Nahori; Guillaume Soubigou; Jean-Yves Coppée; Pascale Cossart; Mélanie A Hamon
Journal:  Science       Date:  2013-08-02       Impact factor: 47.728

Review 3.  Shigella are versatile mucosal pathogens that circumvent the host innate immune system.

Authors:  Hiroshi Ashida; Michinaga Ogawa; Hitomi Mimuro; Taira Kobayashi; Takahito Sanada; Chihiro Sasakawa
Journal:  Curr Opin Immunol       Date:  2011-07-15       Impact factor: 7.486

4.  The phosphothreonine lyase activity of a bacterial type III effector family.

Authors:  Hongtao Li; Hao Xu; Yan Zhou; Jie Zhang; Chengzu Long; Shuqin Li; She Chen; Jian-Min Zhou; Feng Shao
Journal:  Science       Date:  2007-02-16       Impact factor: 47.728

5.  An injected bacterial effector targets chromatin access for transcription factor NF-kappaB to alter transcription of host genes involved in immune responses.

Authors:  Laurence Arbibe; Dong Wook Kim; Eric Batsche; Thierry Pedron; Bogdan Mateescu; Christian Muchardt; Claude Parsot; Philippe J Sansonetti
Journal:  Nat Immunol       Date:  2006-12-10       Impact factor: 25.606

6.  Evidence for the existence of an HP1-mediated subcode within the histone code.

Authors:  Gwen Lomberk; Debora Bensi; Martín E Fernandez-Zapico; Raul Urrutia
Journal:  Nat Cell Biol       Date:  2006-03-12       Impact factor: 28.824

7.  Shigella flexneri targets the HP1γ subcode through the phosphothreonine lyase OspF.

Authors:  Habiba Harouz; Christophe Rachez; Benoit M Meijer; Benoit Marteyn; Françoise Donnadieu; Florence Cammas; Christian Muchardt; Philippe Sansonetti; Laurence Arbibe
Journal:  EMBO J       Date:  2014-09-12       Impact factor: 11.598

8.  A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response.

Authors:  Alice Lebreton; Goran Lakisic; Viviana Job; Lauriane Fritsch; To Nam Tham; Ana Camejo; Pierre-Jean Matteï; Béatrice Regnault; Marie-Anne Nahori; Didier Cabanes; Alexis Gautreau; Slimane Ait-Si-Ali; Andréa Dessen; Pascale Cossart; Hélène Bierne
Journal:  Science       Date:  2011-01-20       Impact factor: 47.728
  8 in total
  3 in total

1.  Macrophages Infected by a Pathogen and a Non-pathogen Spotted Fever Group Rickettsia Reveal Differential Reprogramming Signatures Early in Infection.

Authors:  Pedro Curto; Sean P Riley; Isaura Simões; Juan J Martinez
Journal:  Front Cell Infect Microbiol       Date:  2019-04-10       Impact factor: 5.293

2.  Bioorthogonal Engineering of Bacterial Effectors for Spatial-Temporal Modulation of Cell Signaling.

Authors:  Jingyi Zhao; Yanjun Liu; Feng Lin; Weixia Wang; Shaojun Yang; Yun Ge; Peng R Chen
Journal:  ACS Cent Sci       Date:  2018-12-27       Impact factor: 14.553

Review 3.  Molecular Mechanisms That Define Redox Balance Function in Pathogen-Host Interactions-Is There a Role for Dietary Bioactive Polyphenols?

Authors:  Kaiwen Mu; Danni Wang; David D Kitts
Journal:  Int J Mol Sci       Date:  2019-12-10       Impact factor: 5.923
  3 in total

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