AIM: Vitamin D (VD) was recently associated with response to hepatitis B vaccination in chronic kidney disease. We investigated whether polymorphisms in VD binding protein (GC), VD receptor (VDR) and retinoid X receptor α (RXRA) genes were associated with response to hepatitis B vaccination in renal replacement therapy (RRT) patients. METHOD: The study was carried out on 692 responders and 223 non-responders. RESULTS: After adjustment for gender, age at the RRT onset, RRT vintage, chronic glomerulonephritis as a cause of renal failure and mean serum parathyroid hormone level, VDR rs1544410 polymorphism was the only one significantly associated with response to hepatitis B vaccination: homozygotes AA (adjusted OR 1.50, 95% CI: 1.17-1.94, p = 0.002) had higher risk to be non-responders than GG homozygotes. DISCUSSION: The VDR rs1544410 AA genotype may play a negative role (but not as an independent factor) in determining response to hepatitis B vaccination in RRT patients.
AIM: Vitamin D (VD) was recently associated with response to hepatitis B vaccination in chronic kidney disease. We investigated whether polymorphisms in VD binding protein (GC), VD receptor (VDR) and retinoid X receptor α (RXRA) genes were associated with response to hepatitis B vaccination in renal replacement therapy (RRT) patients. METHOD: The study was carried out on 692 responders and 223 non-responders. RESULTS: After adjustment for gender, age at the RRT onset, RRT vintage, chronic glomerulonephritis as a cause of renal failure and mean serum parathyroid hormone level, VDRrs1544410 polymorphism was the only one significantly associated with response to hepatitis B vaccination: homozygotes AA (adjusted OR 1.50, 95% CI: 1.17-1.94, p = 0.002) had higher risk to be non-responders than GG homozygotes. DISCUSSION: The VDRrs1544410 AA genotype may play a negative role (but not as an independent factor) in determining response to hepatitis B vaccination in RRT patients.
Authors: Sapna P Sadarangani; Inna G Ovsyannikova; Krista Goergen; Diane E Grill; Gregory A Poland Journal: Hum Vaccin Immunother Date: 2016-03-03 Impact factor: 3.452
Authors: Alicja E Grzegorzewska; Monika K Świderska; Adrianna Mostowska; Wojciech Warchoł; Paweł P Jagodziński Journal: Int J Endocrinol Date: 2016-08-23 Impact factor: 3.257
Authors: Brett A McKinney; Caleb Lareau; Ann L Oberg; Richard B Kennedy; Inna G Ovsyannikova; Gregory A Poland Journal: PLoS One Date: 2016-08-11 Impact factor: 3.240
Authors: Alicja E Grzegorzewska; Grzegorz Ostromecki; Paulina Zielińska; Adrianna Mostowska; Zofia Niemir; Magdalena Polcyn-Adamczak; Magdalena Pawlik; Anna Sowińska; Paweł P Jagodziński Journal: Med Sci Monit Date: 2015-11-27