| Literature DB >> 25245762 |
Jamie R Wolstenhulme1, Alex Cavell, Matija Gredičak, Russell W Driver, Martin D Smith.
Abstract
A cascade approach to complex pyrroloindolines bearing all-carbon quaternary stereocentres has been developed. This two-component process uses a chiral ammonium salt to control diastereo- and enantioselectivity in the addition of isocyanides to functionalized alkenes to afford pyrroloindolines with up to three stereocentres. A mechanistic proposal involving intramolecular hydrogen bond activation of the isocyanide is described.Entities:
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Year: 2014 PMID： 25245762 DOI： 10.1039/c4cc06683a
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222