Literature DB >> 2524463

Mechanism of activation of the antitumor antibiotic neocarzinostatin by mercaptan and sodium borohydride.

O D Hensens1, I H Goldberg.   

Abstract

The structures of mercaptan and sodium borohydride reaction products of neocarzinostatin chromophore A (NCS Chrom A) are compared. Implications on the mechanism of activation of NCS are discussed.

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Year:  1989        PMID： 2524463     DOI： 10.7164/antibiotics.42.761

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  5 in total

1.  Selective abstraction of 2H from C-5' of thymidylate in an oligodeoxynucleotide by the radical center at C-6 of the diradical species of neocarzinostatin: chemical evidence for the structure of the activated drug-DNA complex.

Authors:  S M Meschwitz; I H Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-15       Impact factor: 11.205

2.  Molecular models of neocarzinostatin damage of DNA: analysis of sequence dependence in 5'GAGCG:5'CGCTC.

Authors:  A Galat; I H Goldberg
Journal:  Nucleic Acids Res       Date:  1990-04-25       Impact factor: 16.971

3.  Spontaneous generation of a biradical species of neocarzinostatin chromophore: role in DNA bulge-specific cleavage.

Authors:  O D Hensens; D H Chin; A Stassinopoulos; D L Zink; L S Kappen; I H Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-10       Impact factor: 11.205

4.  Selective proteolytic activity of the antitumor agent kedarcidin.

Authors:  N Zein; A M Casazza; T W Doyle; J E Leet; D R Schroeder; W Solomon; S G Nadler
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-01       Impact factor: 11.205

5.  Kedarcidin chromophore: an enediyne that cleaves DNA in a sequence-specific manner.

Authors:  N Zein; K L Colson; J E Leet; D R Schroeder; W Solomon; T W Doyle; A M Casazza
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205
  5 in total

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