Literature DB >> 25244570

Extracellular vesicles as enhancers of virus vector-mediated gene delivery.

Zachary Fitzpatrick1, Bence György, Johan Skog, Casey A Maguire.   

Abstract

Extracellular vesicles (EVs) being released from two adjacent adeno-associated virus serotype 1 (AAV1)-producing 293T cells are shown by electron microscopy. We have shown that AAV vectors can associate with EVs and enter the media. Furthermore, we have recently reported that EV-associated AAV has robust gene delivery and antibody evasion properties in vivo.

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Year:  2014        PMID： 25244570      PMCID： PMC4174420          DOI： 10.1089/hum.2014.082

Source DB:  PubMed          Journal:  Hum Gene Ther        ISSN： 1043-0342            Impact factor:   5.695


  4 in total

1.  Efficient serotype-dependent release of functional vector into the culture medium during adeno-associated virus manufacturing.

Authors:  Luk H Vandenberghe; Ru Xiao; Martin Lock; Jianping Lin; Michael Korn; James M Wilson
Journal:  Hum Gene Ther       Date:  2010-10       Impact factor: 5.695

2.  Microvesicle-associated AAV vector as a novel gene delivery system.

Authors:  Casey A Maguire; Leonora Balaj; Sarada Sivaraman; Matheus H W Crommentuijn; Maria Ericsson; Lucia Mincheva-Nilsson; Vladimir Baranov; Davide Gianni; Bakhos A Tannous; Miguel Sena-Esteves; Xandra O Breakefield; Johan Skog
Journal:  Mol Ther       Date:  2012-02-07       Impact factor: 11.454

3.  Naturally enveloped AAV vectors for shielding neutralizing antibodies and robust gene delivery in vivo.

Authors:  Bence György; Zachary Fitzpatrick; Matheus H W Crommentuijn; Dakai Mu; Casey A Maguire
Journal:  Biomaterials       Date:  2014-06-07       Impact factor: 12.479

4.  A pathogenic picornavirus acquires an envelope by hijacking cellular membranes.

Authors:  Zongdi Feng; Lucinda Hensley; Kevin L McKnight; Fengyu Hu; Victoria Madden; Lifang Ping; Sook-Hyang Jeong; Christopher Walker; Robert E Lanford; Stanley M Lemon
Journal:  Nature       Date:  2013-03-31       Impact factor: 49.962
  4 in total
  6 in total

1.  Rescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV.

Authors:  Bence György; Cyrille Sage; Artur A Indzhykulian; Deborah I Scheffer; Alain R Brisson; Sisareuth Tan; Xudong Wu; Adrienn Volak; Dakai Mu; Panos I Tamvakologos; Yaqiao Li; Zachary Fitzpatrick; Maria Ericsson; Xandra O Breakefield; David P Corey; Casey A Maguire
Journal:  Mol Ther       Date:  2017-01-09       Impact factor: 11.454

2.  Adeno-Associated Virus 5 Transduces Adipose-Derived Stem Cells with Greater Efficacy Than Other Adeno-Associated Viral Serotypes.

Authors:  Priyanka Sharma; Sunishka M Wimalawansa; Gregory C Gould; R Michael Johnson; Katherine J D A Excoffon
Journal:  Hum Gene Ther Methods       Date:  2016-11-07       Impact factor: 2.396

Review 3.  Strategies to circumvent humoral immunity to adeno-associated viral vectors.

Authors:  Longping V Tse; Sven Moller-Tank; Aravind Asokan
Journal:  Expert Opin Biol Ther       Date:  2015-06       Impact factor: 4.388

Review 4.  Microparticles: biogenesis, characteristics and intervention therapy for cancers in preclinical and clinical research.

Authors:  Yan Hu; Yajie Sun; Chao Wan; Xiaomeng Dai; Shuhui Wu; Pui-Chi Lo; Jing Huang; Jonathan F Lovell; Honglin Jin; Kunyu Yang
Journal:  J Nanobiotechnology       Date:  2022-04-13       Impact factor: 10.435

5.  Gene Therapy in Mouse Models of Deafness and Balance Dysfunction.

Authors:  Lingyan Wang; J Beth Kempton; John V Brigande
Journal:  Front Mol Neurosci       Date:  2018-08-29       Impact factor: 5.639

6.  Site-Specific PEGylated Adeno-Associated Viruses with Increased Serum Stability and Reduced Immunogenicity.

Authors:  Tianzhuo Yao; Xueying Zhou; Chuanling Zhang; Xiaojuan Yu; Zhenyu Tian; Lihe Zhang; Demin Zhou
Journal:  Molecules       Date:  2017-07-11       Impact factor: 4.411
  6 in total

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