Literature DB >> 25244003

Mohs micrographic surgery in dermatofibrosarcoma protuberans allows tumour clearance with smaller margins and greater preservation of healthy tissue compared with conventional surgery: a study of 74 primary cases.

C Serra-Guillén1, B Llombart1, E Nagore1,2, C Guillén1, C Requena1, V Traves3, S Kindem1, R Alcalá1, N Rivas1, O Sanmartín1,2.   

Abstract

BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) is an uncommon skin tumour with aggressive local growth. Whether DFSP should be treated with conventional surgery (CS) or Mohs micrographic surgery (MMS) has long been a topic of debate.
OBJECTIVES: To calculate, in a large series of DFSP treated by MMS, the minimum margin that would have been needed to achieve complete clearance by CS. Secondly, to calculate the percentage of healthy tissue that was preserved by MMS rather than CS with 2- and 3-cm margins.
METHODS: The minimum margin was calculated by measuring the largest distance from the visible edge of the tumour to the edge of the definitive surgical defect. Tumour and surgical defect areas for hypothetical CS with 2- and 3-cm margins were calculated using AutoCAD for Windows.
RESULTS: A mean minimum margin of 1·34 cm was required to achieve complete clearance for the 74 tumours analysed. The mean percentages of skin spared using MMS rather than CS with 2- and 3-cm margins were 49·4% and 67·9%, respectively.
CONCLUSIONS: MMS can achieve tumour clearance with smaller margins and greater preservation of healthy tissue than CS.
© 2014 British Association of Dermatologists.

Entities:  

Mesh:

Year:  2015        PMID: 25244003     DOI: 10.1111/bjd.13417

Source DB:  PubMed          Journal:  Br J Dermatol        ISSN: 0007-0963            Impact factor:   9.302


  11 in total

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4.  Wide Local Excision for Dermatofibrosarcoma Protuberans: A Single-Center Series of 90 Patients.

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5.  Dermatofibrosarcoma protuberans with fibrosarcomatous transformation.

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8.  Clinicopathological features of fibrosarcomatous dermatofibrosarcoma protuberans and the construction of a back-propagation neural network recognition model.

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Review 10.  Dermatofibrosarcoma Protuberans: Insights into a Rare Soft Tissue Tumor.

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