OBJECTIVE: To construct and analyze the differential expression profiles of microRNAs (miRNA) and mRNA in oral squamous cell carcinoma (OSCC). To explore the miRNA and mRNA of OSCC development and progression. METHODS: The differential expression profiles of miRNA and mRNA were built by high-throughput deep sequencing technology. Using Gene Ontology (GO) enrichment analysis, the roles of differentially expressed miRNA and mRNA in cell cycle, cell proliferation, cell differentiation and cell apoptosis were analyzed. RESULTS: Seventy-seven differentially expressed miRNA and 1 298 differentially expressed mRNAs were identified in OSCC. GO analysis showed that 73 miRNA had found target mRNA in cell cycle, cell proliferation, cell differentiation and cell apoptosis of OSCC. Moreover, a miRNA could regulate multiple mRNA. CONCLUSION: The differential expression profiles of miRNA and mRNA have close relationship with the development and progression of OSCC.
OBJECTIVE: To construct and analyze the differential expression profiles of microRNAs (miRNA) and mRNA in oral squamous cell carcinoma (OSCC). To explore the miRNA and mRNA of OSCC development and progression. METHODS: The differential expression profiles of miRNA and mRNA were built by high-throughput deep sequencing technology. Using Gene Ontology (GO) enrichment analysis, the roles of differentially expressed miRNA and mRNA in cell cycle, cell proliferation, cell differentiation and cell apoptosis were analyzed. RESULTS: Seventy-seven differentially expressed miRNA and 1 298 differentially expressed mRNAs were identified in OSCC. GO analysis showed that 73 miRNA had found target mRNA in cell cycle, cell proliferation, cell differentiation and cell apoptosis of OSCC. Moreover, a miRNA could regulate multiple mRNA. CONCLUSION: The differential expression profiles of miRNA and mRNA have close relationship with the development and progression of OSCC.
Authors: Fabian Birzele; Jochen Schaub; Werner Rust; Christoph Clemens; Patrick Baum; Hitto Kaufmann; Andreas Weith; Torsten W Schulz; Tobias Hildebrandt Journal: Nucleic Acids Res Date: 2010-03-01 Impact factor: 16.971
Authors: Brian J Henson; Samsiddhi Bhattacharjee; Dawn M O'Dee; Eleanor Feingold; Susanne M Gollin Journal: Genes Chromosomes Cancer Date: 2009-07 Impact factor: 5.006
Authors: Cesar Lopez-Camarillo; Laurence A Marchat; Elena Arechaga-Ocampo; Carlos Perez-Plasencia; Oscar Del Moral-Hernandez; Elizabeth J Castaneda-Ortiz; Sergio Rodriguez-Cuevas Journal: Int J Mol Sci Date: 2012-01-27 Impact factor: 6.208