Camila Pinheiro Furquim1, Allana Pivovar2, Laura Grein Cavalcanti3, Renata Fuentes Araújo4, Carmem Maria Sales Bonfim5, Cassius Carvalho Torres-Pereira6. 1. Federal University of Paraná School of Dentistry, Curitiba, Paraná, Brazil. 2. Federal University of Paraná School of Dentistry, Curitiba, Paraná, Brazil. Electronic address: lana.pivovar@gmail.com. 3. Postgraduate Program in Dentistry, Federal University of Paraná, Curitiba, Paraná, Brazil. 4. Postgraduate Program in Dentistry, Hospital de Clínicas, Federal University of Paraná, Curitiba, Paraná, Brazil. 5. Bone Marrow Transplantation Unit, Hospital de Clínicas, Federal University of Paraná, Curitiba, Paraná, Brazil. 6. Postgraduate Program in Dentistry, Department of Stomatology, Federal University of Paraná, Curitiba, Paraná, Brazil.
Abstract
OBJECTIVE: Oral cancer usually occurs at accessible sites, enabling early detection by visual inspection. Fanconi anemia (FA) is a recessive disorder associated with a high risk of developing head and neck solid tumors. The aim of this study was to assess the ability to perform mouth self-examination (MSE) in these patients. STUDY DESIGN: A total of 44 patients with FA, aged ≥ 18 years, were given a self-reported questionnaire to collect sociodemographic data and information about health-related behaviors and oral cancer awareness. They were asked to perform MSE, which was evaluated using criteria for mucosal visualization and retracting ability. Subsequently, an oral medicine specialist clinically examined all participants, and these findings were considered to be the gold standard. RESULTS: The sensitivity and specificity values of MSE were 43% and 44%, respectively. The MSE accuracy was 43%. Most patients (73%) reported that MSE was easy or very easy, although 75% showed insufficient performance. CONCLUSIONS: The accuracy of MSE alone is not sufficient to indicate whether MSE should be recommended as a strategy to prevent oral cancer in patients with FA. Nevertheless, the present results indicate that this inexpensive technique could be used as a tool for early detection of cancer in these patients.
OBJECTIVE:Oral cancer usually occurs at accessible sites, enabling early detection by visual inspection. Fanconi anemia (FA) is a recessive disorder associated with a high risk of developing head and neck solid tumors. The aim of this study was to assess the ability to perform mouth self-examination (MSE) in these patients. STUDY DESIGN: A total of 44 patients with FA, aged ≥ 18 years, were given a self-reported questionnaire to collect sociodemographic data and information about health-related behaviors and oral cancer awareness. They were asked to perform MSE, which was evaluated using criteria for mucosal visualization and retracting ability. Subsequently, an oral medicine specialist clinically examined all participants, and these findings were considered to be the gold standard. RESULTS: The sensitivity and specificity values of MSE were 43% and 44%, respectively. The MSE accuracy was 43%. Most patients (73%) reported that MSE was easy or very easy, although 75% showed insufficient performance. CONCLUSIONS: The accuracy of MSE alone is not sufficient to indicate whether MSE should be recommended as a strategy to prevent oral cancer in patients with FA. Nevertheless, the present results indicate that this inexpensive technique could be used as a tool for early detection of cancer in these patients.
Authors: Tanya Walsh; Saman Warnakulasuriya; Mark W Lingen; Alexander R Kerr; Graham R Ogden; Anne-Marie Glenny; Richard Macey Journal: Cochrane Database Syst Rev Date: 2021-12-10