Marco Innamorati1, Zoltan Rihmer2, Hagop Akiskal3, Xenia Gonda4, Denise Erbuto1, Martino Belvederi Murri5, Giulio Perugi6, Mario Amore5, Paolo Girardi1, Maurizio Pompili7. 1. Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant׳Andrea Hospital, Sapienza University of Rome, Rome, Italy. 2. Department of Clinical and Theoretical Mental Health, Kútvölgyi Clinical Center, Semmelweis University, Budapest, Hungary. 3. San Diego Veterans Administration Medical Center, San Diego, CA, USA; International Mood Center, La Jolla, CA, USA. 4. Department of Clinical and Theoretical Mental Health, Kútvölgyi Clinical Center, Semmelweis University, Budapest, Hungary; Laboratory of Suicide Prevention and Research, National Institute for Psychiatry and Addictology, Department of Pharmacology and Pharmacotherapy, Semmelweis University, Hungary; MTA-SE Neurochemistry Research Group, Hungary. 5. Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genova, Genova, Italy. 6. Department of Psychiatry, University of Pisa, Pisa, Italy. 7. Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant׳Andrea Hospital, Sapienza University of Rome, Rome, Italy. Electronic address: maurizio.pompili@uniroma1.it.
Abstract
BACKGROUND: The aim of the present study was to assess sociodemographic and clinical differences between inpatients with major mood disorders (bipolar disorder - BD - and major depression - MDD) and the cyclothymic phenotype (CYC), and pure BDs or MDDs. METHODS: Participants were 281 adult inpatients (134 men and 147 women) consecutively admitted to the Department of Psychiatry of the Sant׳Andrea University Hospital in Rome, Italy, between January 2008 and June 2010. The patients completed the Hamilton Scale for Depression (HAMD17), the Young Mania Rating Scale, the TEMPS-A (Temperament Evaluation of the Memphis, Pisa, Paris and San Diego-Autoquestionnaire), and the Beck Hopelessness Scale. RESULTS: 38.7% of the MDD patients and 48.3% of the BD patients satisfied criteria to be included in the cyclothymic groups. Above 92% of the patients with the cyclothymic phenotype reported suicidal ideation at the item #3 of the HAMD17. Furthermore, patients with the cyclothymic phenotype reported higher hopelessness than other patients. LIMITATIONS: Our results are potentially limited by the small number of MDD-CYC patients included in the sample. CONCLUSIONS: Our results support the clinical usefulness of the concept of soft bipolar spectrum. Patients with the cyclothymic phenotype differ from pure MDD patients and BD patients for temperamental profile and clinical variables.
BACKGROUND: The aim of the present study was to assess sociodemographic and clinical differences between inpatients with major mood disorders (bipolar disorder - BD - and major depression - MDD) and the cyclothymic phenotype (CYC), and pure BDs or MDDs. METHODS:Participants were 281 adult inpatients (134 men and 147 women) consecutively admitted to the Department of Psychiatry of the Sant׳Andrea University Hospital in Rome, Italy, between January 2008 and June 2010. The patients completed the Hamilton Scale for Depression (HAMD17), the Young Mania Rating Scale, the TEMPS-A (Temperament Evaluation of the Memphis, Pisa, Paris and San Diego-Autoquestionnaire), and the Beck Hopelessness Scale. RESULTS: 38.7% of the MDDpatients and 48.3% of the BD patients satisfied criteria to be included in the cyclothymic groups. Above 92% of the patients with the cyclothymic phenotype reported suicidal ideation at the item #3 of the HAMD17. Furthermore, patients with the cyclothymic phenotype reported higher hopelessness than other patients. LIMITATIONS: Our results are potentially limited by the small number of MDD-CYCpatients included in the sample. CONCLUSIONS: Our results support the clinical usefulness of the concept of soft bipolar spectrum. Patients with the cyclothymic phenotype differ from pure MDDpatients and BD patients for temperamental profile and clinical variables.
Authors: Bojan Mirkovic; Véronique Delvenne; Marion Robin; Alexandra Pham-Scottez; Maurice Corcos; Mario Speranza Journal: BMC Psychiatry Date: 2021-08-09 Impact factor: 3.630