Anna Giulia Falchi1, Ilaria Grecchi2, Chiara Muggia2, Carmine Tinelli3. 1. Department of Internal Medicine and Therapeutics, Clinica Medica II, Vascular and Metabolic Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy. Electronic address: a.falchi@smatteo.pv.it. 2. Department of Internal Medicine and Therapeutics, Clinica Medica II, Vascular and Metabolic Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy. 3. Clinical Epidemiology and Biometric Unit, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy.
Abstract
BACKGROUND: The aim of this study is to investigate if therapeutic weight loss reduces P wave dispersion. METHODS:20 obese patients (10 males and 10 females), part of a randomized clinical trial, were examined over a 6 month period. They were treated with a diet, aiming at 5% weight loss at the 6th month. After physical examination, they underwent laboratory tests, bioelectrical impedance analysis and a electrocardiogram (ECG). ECGs were transferred to a personal computer via a scanner and then magnified 400 times. We examined at baseline and at the 6th month, maximum and minimum P-wave duration, P-wave dispersion and heart rate. RESULTS: Comparing responders (patients who lost 5% of weight at t6) and not responders (who lost less than 5%), responders showed a significant reduction of P wave dispersion value (-0.38 [SD: 0.35] mm equal to -32.3 [SD: 11.3] % p=0.00001). All responders present a reduction of P wave dispersion, while for not-responders this is no longer evident. Finally, a good degree of correlation (r=0.54) between P wave dispersion difference and the decrease of weight was noticed. Females have a better response in P dispersion reduction strictly connected with their weight loss with a good correlation, (r=0.7, p=0.002), versus a moderate correlation evidenced in males (r=0.5, p=0.011). CONCLUSION: P wave duration and dispersion are significantly reduced in patients who lost more than 5% of weight and this decrease is highly related to the extent of weight loss.
RCT Entities:
BACKGROUND: The aim of this study is to investigate if therapeutic weight loss reduces P wave dispersion. METHODS: 20 obesepatients (10 males and 10 females), part of a randomized clinical trial, were examined over a 6 month period. They were treated with a diet, aiming at 5% weight loss at the 6th month. After physical examination, they underwent laboratory tests, bioelectrical impedance analysis and a electrocardiogram (ECG). ECGs were transferred to a personal computer via a scanner and then magnified 400 times. We examined at baseline and at the 6th month, maximum and minimum P-wave duration, P-wave dispersion and heart rate. RESULTS: Comparing responders (patients who lost 5% of weight at t6) and not responders (who lost less than 5%), responders showed a significant reduction of P wave dispersion value (-0.38 [SD: 0.35] mm equal to -32.3 [SD: 11.3] % p=0.00001). All responders present a reduction of P wave dispersion, while for not-responders this is no longer evident. Finally, a good degree of correlation (r=0.54) between P wave dispersion difference and the decrease of weight was noticed. Females have a better response in P dispersion reduction strictly connected with their weight loss with a good correlation, (r=0.7, p=0.002), versus a moderate correlation evidenced in males (r=0.5, p=0.011). CONCLUSION: P wave duration and dispersion are significantly reduced in patients who lost more than 5% of weight and this decrease is highly related to the extent of weight loss.
Authors: Andrés Ricardo Pérez-Riera; Luiz Carlos de Abreu; Raimundo Barbosa-Barros; José Grindler; Acácio Fernandes-Cardoso; Adrian Baranchuk Journal: Indian Pacing Electrophysiol J Date: 2016-10-20